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Recombinant Human FGL1 Protein (mFc Tag)

Uniprot : Q08830
  • Cat.No.:PKSH033679

  • Expression host: HEK293 Cells

To Purchase PKSH033679

Size:
  • 10µg
  • 50µg
Price: $178
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Description

Synonyms Fibrinogen-like protein 1;FGL1;HP-041;Hepassocin;HFREP-1;LFIRE-1
Species Human
Expression_host HEK293 Cells
Sequence Leu23-Ile312
Accession Q08830
Application Functional ELISA
Mol_Mass 60.6 kDa
AP_Mol_Mass 60-65 kDa
Tag C-mFc
Bio_Activity Immobilized Human LAG-3(Cat: PKSH033596) at 5μg/ml(100 μl/well) can bind Human FGL1-Fc. The ED50 of Human FGL1-Fc is 30-90 ng/ml.

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manua
Reconstitution Please refer to the printed manual for detailed information.

Background

Hepassocin; also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1); is a liver-specific secreted protein belonging to the fibronogen superfamily; whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .

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