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Cat.No.:E-AB-F1199UM
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Alternate Names | Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8 |
Swissprot | Q62386 |
References |
1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego.
2. Numasaki M, et al. 2002. Blood 101:2620. 3. Fossiez F, et al. 1996. J. Exp. Med. 183:2593. 4. Yao Z, et al. 1997. Cytokine 9:794. 5. Dong C. 2006. Nat. Rev. Immunol. 6:329. 6. Hofstetter HH, et al. 2005 Cell. Immunol. 237:123. |
Form | Liquid |
Clone No. | TC11-18H10.1 |
Host | Rat |
Isotype | Rat IgG1, κ |
Isotype Control | Elab Fluor® 647 Rat IgG1, κ Isotype Control[HRPN] [Product E-AB-F09823M] |
Reactivity | Mouse |
Application | ICFCM |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Recommended Use | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume]. |
Shipping | Biological ice pack at 4℃ |
Stability & Storage | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Conjugation | Elab Fluor® 647 |
Elab Fluor® 647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter). | |
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How to select the appropriate detection channel through the spectrogram?
IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
Related Protocols | Staining Intracellular Antigens for Flow Cytometry |
Troubleshooting |
Product Name | Sizes | Price |
Biotin Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 25μg, 100μg | Check More |
FITC Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 50Tests, 100Tests, 100Tests×2 | Check More |
PE Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 50Tests, 100Tests, 100Tests×2 | Check More |
APC Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 50Tests, 100Tests, 100Tests×2 | Check More |
Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 50Tests, 100Tests, 100Tests×2 | Check More |
FITC Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 25μg, 100μg | Check More |
PE Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 25μg, 100μg | Check More |
APC Anti-Mouse IL-17A Antibody[TC11-18H10.1] | 25μg, 100μg | Check More |