Alternate Names	Interleukin-17A,Il17a,Ctla8
Swissprot	Q62386
Gene ID	16171
References	1. Faraco,G, et al. 2018. Nat Neurosci. 21(2): 240-249. 2. Xiong H, et al. 2016. Cell. 03.017. 3. Coffelt S, et al. 2015. Nature. 522(7556): 345-348. 4. Naik S, et al. 2015. Nature. 520(7545): 104-108. 5. Sell S, et al. 2015. PLoS Pathog. 11(2): e1004481.

Product Details

Form	Liquid
Clone No.	17F3
Host	Mouse
Isotype	Mouse IgG1, κ
Isotype Control	PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21] [Product E-AB-F09793H]
Reactivity	Mouse
Application	ICFCM
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use	Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10⁶ cells in 100 μL volume].
Shipping	Biological ice pack at 4℃
Stability & Storage	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Conjugation	PE/Cyanine7
	PE/Cyanine7 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 775 nm (e.g., a 780/60 nm bandpass filter).

How to select the appropriate detection channel through the spectrogram?

Background

The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-41A in vivo.

Protocols & Troubleshootings

Related Protocols	Staining Intracellular Antigens for Flow Cytometry
Troubleshooting	Troubleshooting for Flow Cytometry

Alternative Formats

Product Name	Sizes	Price
FITC Anti-Mouse IL-17A Antibody[17F3]	50Tests, 100Tests, 100Tests×2	Check More
PE Anti-Mouse IL-17A Antibody[17F3]	50Tests, 100Tests, 100Tests×2	Check More
APC Anti-Mouse IL-17A Antibody[17F3]	50Tests, 100Tests, 100Tests×2	Check More
PE/Cyanine7 Anti-Mouse IL-17A Antibody[17F3]	50Tests, 100Tests, 100Tests×2	Check More
Elab Fluor^® Violet 450 Anti-Mouse IL-17A Antibody[17F3]	50Tests, 100Tests, 100Tests×2	Check More
FITC Anti-Mouse IL-17A Antibody[17F3]	25μg, 100μg	Check More
PE Anti-Mouse IL-17A Antibody[17F3]	25μg, 100μg	Check More
APC Anti-Mouse IL-17A Antibody[17F3]	25μg, 100μg	Check More
Elab Fluor^® Violet 450 Anti-Mouse IL-17A Antibody[17F3]	25μg, 100μg	Check More

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