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Recombinant Human Cathepsin B/CTSB Protein (His Tag)

Uniprot : P07858
  • Cat.No.:PKSH032179

  • Expression host: Human Cells

To Purchase PKSH032179

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  • 10µg
  • 50µg
Price: $223
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Description

Synonyms Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB
Species Human
Expression_host Human Cells
Sequence Arg18-Ile339
Accession AAH10240.1
Mol_Mass 36.9 kDa
AP_Mol_Mass 34 & 38-50 kDa
Tag C-6His

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Formulation Supplied as a 0.2 μM filtered solution of PBS, pH 7.4.
Reconstitution Not Applicable

Background

Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes

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