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Recombinant Human PD-L1/B7-H1/CD274 Protein (His Tag)

Uniprot : Q9NZQ7

Cat.No.:PKSH033557
Expression host: HEK293 Cells

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Description

Synonyms	Programmed Cell Death 1 Ligand 1;PD-L1;PDCD1 Ligand 1;Programmed Death Ligand 1;B7 Homolog 1;B7-H1;CD274;B7H1;PDCD1L1;PDCD1LG1;PDL1
Species	Human
Expression_host	HEK293 Cells
Sequence	Phe19-Thr239
Accession	Q9NZQ7
Application	Functional ELISA
Mol_Mass	26.3 kDa
AP_Mol_Mass	34-42 kDa
Tag	C-His
Bio_Activity	Immobilized Anti-Human PDL1 mAb at 2μg/ml (100 μl/well)can bind Human PD-L1-His.The ED50 of Human PD-L1-6His is 5.57 ng/ml.

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 4% Mannitol, 0.02% Tween 80, pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

CD274; also known as B7-H1 or programmed death ligand 1 (PD-L1); is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1; CD274; B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells; PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly; it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

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