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Human IL-1β(Interleukin 1 Beta) ELISA Kit

Citations(206)Uniprot : P01584

Cat.No.:E-EL-H0149
Reactivity: Human

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96T
48T
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96T*5
96T*10

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Product Details

Properties

Assay type	Sandwich-ELISA
Format	96T/48T/24
Assay time	3.5h
Detection range	7.81-500 pg/mL
Sensitivity	4.69 pg/mL
Sample type &Sample volume	serum, plasma and other biological fluids; 100μL
Specificity	This kit recognizes Human IL-1β in samples. No significant cross-reactivity or interference between Human IL-1β and analogues was observed.
Reproducibility	Both intra-CV and inter-CV are < 10%.
Application	This ELISA kit applies to the in vitro quantitative determination of Human IL-1β concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-1β. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Human IL-1β and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IL-1β, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Human IL-1β. You can calculate the concentration of Human IL-1β in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.

Item	Specifications	Storage
Micro ELISA Plate(Dismountable)	96T: 8 wells ×12 strips 48T: 8 wells ×6 strips	-20℃, 12 months
Reference Standard	96T: 2 vials 48T: 1 vial
Concentrated Biotinylated Detection Ab (100×)	96T: 1 vial, 120 μL 48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×)	96T: 1 vial, 120 μL 48T: 1 vial, 60 μL	-20℃(Protect from light), 12 months
Reference Standard & Sample Diluent	1 vial, 20 mL	2-8°C, 12 months
Biotinylated Detection Ab Diluent	1 vial, 14 mL
HRP Conjugate Diluent	1 vial, 14 mL
Concentrated Wash Buffer (25×)	1 vial, 30 mL
Substrate Reagent	1 vial, 10 mL	2-8℃(Protect from light)
Stop Solution	1 vial, 10 mL	2-8°C
Plate Sealer	5 pieces
Manual	1 copy
Certificate of Analysis	1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Human IL-1β were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Human IL-1β were tested on 3 different plates, 20 replicates in each plate.

	Intra-assay Precision			Inter-assay Precision
Sample	1	2	3	1	2	3
n	20	20	20	20	20	20
Mean (pg/mL)	27.70	46.20	197.60	29.10	47.80	192.60
Standard deviation	1.40	2.60	9.50	1.70	2.80	6.00
CV (%)	5.05	5.63	4.81	5.84	5.86	3.12

Recovery

The recovery of Human IL-1β spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type	Range (%)	Average Recovery (%)
Serum(n=8)	94-110	100
EDTA plasma (n=8)	89-102	95
Cell culture media (n=8)	84-98	91

Linearity

Samples were spiked with high concentrations of Human IL-1β and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database Links	SwissProt: P01584
Synonyms	IL1B, IL1-BETA, IL1F2, catabolin
Research Area	Cancer, Cardiovascular, Metabolism, Immunology

Assay Procedures

	1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C
	2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C
	3. Aspirate and wash the plate for 3 times
	4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times
	5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C
	6. Add 50μL Stop Solution
	7. Read the plate at 450nm immediately. Calculation of the results

Citations

Aging-US (2020) IF: 4.831

K63 ubiquitin chains target NLRP3 inflammasome for autophagic degradation in ox-LDL-stimulated THP-1 macrophages

DOI: 10.18632/aging.102710
PMID: 32003754	Sample: Cell Culture Supernatant

Aging-US (2020) IF: 4.831

Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation

DOI: 10.18632/aging.103038
	Sample: Thp-1 Cell

Frontiers in Nutrition (2022) IF: 6.59

Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets.

DOI: 10.3389/fnut.2022.974694
	Sample: Serum

Cell Death Discovery (2017) IF: 5.241

The principles and attentions of Immunohistochemistry

DOI: 10.1038/cddiscovery.2016.107
	Sample: Nucleus Pulposus (Np) Cell

Frontiers in Pharmacology (2022) IF: 5.988

MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation

DOI: 10.3389/fphar.2022.978587
PMID: 36091773	Sample: U87 Cell

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208

Nanoparticle Emulsions Enhance the Inhibition of NLRP3

DOI: 10.3390/ijms231710168
PMID: 36077562	Sample: Thp-1 Cell

PHYTOTHERAPY RESEARCH (2021) IF: 5.882

Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial

DOI: 10.1002/ptr.7113
PMID: 33899292	Sample: Serum

DIABETOLOGIA (2018) IF: 6.023

receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes

DOI: 10.1007/s00125-018-4755-3
	Sample: Cell Culture Supernatant

Frontiers in Bioengineering and Biotechnology (2022) IF: 6.064

Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration.

DOI: 10.3389/fbioe.2022.883118
	Sample: Human Primary Nucleus Pulposus Cell (Hnpc)

Frontiers in Cellular Neuroscience (2022) IF: 6.147

The SARS-CoV-2 envelope protein disrupts barrier function in an in vitro human blood-brain barrier model.

DOI: 10.3389/fncel.2022.897564
	Sample: Hcmec/D3 Cell,U87Mg Cell

Cancers (2019) IF: 6.162

GSTO1*CC Genotype (rs4925) Predicts Shorter Survival in Clear Cell Renal Cell Carcinoma Male Patients

DOI: 10.3390/cancers11122038
PMID: 31861116	Sample: Serum,Plasma,Whole Blood,Platelet

Frontiers in Pharmacology (2022) IF: 5.988

Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization

DOI: 10.3389/fphar.2022.932198
PMID: 35873581	Sample: Thp-1 Cell

Marine Drugs (2023) IF: 6.085

Mechanisms of Antitumor Invasion and Metastasis of the Marine Fungal Derivative Epi-Aszonalenin A in HT1080 Cells

DOI: 10.3390/md21030156
	Sample: Ht1080 Cell

EBioMedicine (2018) IF: 6.183

The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway

DOI: 10.1016/j.ebiom.2018.11.015
PMID: 30448228	Sample: Cell Culture Supernatant

Frontiers in Pharmacology (2022) IF: 5.988

Aconiti lateralis radix praeparata total alkaloids exert anti-RA effects by regulating NF-κB and JAK/STAT signaling pathways and promoting apoptosis.

DOI: 10.3389/fphar.2022.980229
	Sample: Mh7A Cell

JOURNAL OF MEDICAL INVESTIGATION (2022)

Comparing the ICSI outcome between different causes of subfertility and estimate the role of IL-1β in predicting ICSI outcome.

DOI: 10.2152/jmi.69.180
	Sample: Follicular Fluid,Serum

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2022) IF: 0.533

Dysfunctional oxidative stress response in first-episode of schizophrenia

DOI: 10.4314/tjpr.v20i6.22
	Sample: Serum

Genetic Testing and Molecular Biomarkers (2019) IF: 1.121

Association of PAR-2 Gene Polymorphisms with the Inflammatory Response and Susceptibility to Knee Osteoarthritis in the Chinese Han Population

DOI: 10.1089/gtmb.2018.0219
PMID: 30688539	Sample: Synovia

Experimental and Therapeutic Medicine (2017) IF: 1.261

Inhibition of miR‑27a suppresses the inflammatory response via the p38/MAPK pathway in intervertebral disc cells

DOI: 10.3892/etm.2017.5053
	Sample: Cell Culture Supernatant

EPILEPTIC DISORDERS (2020) IF: 1.276

HMGB‐1, TLR4, IL‐1R1, TNF‐α, and IL‐1β: novel epilepsy markers?

DOI: 10.1684/epd.2020.1155
	Sample: Serum

International Journal of Clinical and Experimental Pathology (2018) IF: 1.396

MicroRNA-124 alleviates hyperoxia-induced inflammatory response in pulmonary epithelial cell by inhibiting TLR4/NF-κB/CCL2


PMID: 31938089	Sample: Beas2B Cells

Experimental and Therapeutic Medicine (2018) IF: 1.41

Role of miR‑589‑3p in human lumbar disc degeneration and its potential mechanism

DOI: 10.3892/etm.2017.5593
	Sample: Cell Culture Supernatant

Experimental and Therapeutic Medicine (2018) IF: 1.41

N‑methyl pyrrolidone promotes ankle fracture healing by inhibiting inflammation via suppression of the mitogen‑activated protein kinase signaling pathway

DOI: 10.3892/etm.2018.5842
	Sample: Peripheral Blood

Experimental and Therapeutic Medicine (2018) IF: 1.41

Anti‑inflammatory effect of Resolvin D1 on LPS‑treated MG‑63 cells Corrigendum in /10.3892/etm.2019.8021

DOI: 10.3892/etm.2018.6721
	Sample: Serum

JOURNAL OF CLINICAL NEUROSCIENCE (2019) IF: 1.593

Sex difference in IL-6 modulation of cognition among Chinese individuals with major depressive disorder

DOI: 10.1016/j.jocn.2019.10.002
PMID: 31629608	Sample: Serum

ARCHIVES OF ORAL BIOLOGY (2019) IF: 1.663

Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts

DOI: 10.1016/j.archoralbio.2019.104514
PMID: 31394382	Sample: Cell Culture Supernatant

Molecular Medicine Reports (2017) IF: 1.692

Tetrahydroxy stilbene glucoside ameliorates H2O2-induced human brain microvascular endothelial cell dysfunction in vitro by inhibiting oxidative stress and inflammatory responses

DOI: 10.3892/mmr.2017.7225
	Sample: Cell Culture Supernatant

International Journal of Ophthalmology (2021) IF: 1.779

Effects of quercetin on diabetic retinopathy and its association with NLRP3 inflammasome and autophagy

DOI: 10.18240/ijo.2021.01.06
PMID: 33469482	Sample: Cell Culture Supernatant

MEDICAL SCIENCE MONITOR (2018) IF: 1.894

Sinomenine Regulates Inflammatory Response and Oxidative Stress via Nuclear Factor kappa B (NF-κB) and NF-E2-Related Factor 2 (Nrf2) Signaling Pathways in Ankle Fractures in Children

DOI: 10.12659/MSM.910740
	Sample: Serum

MEDICAL SCIENCE MONITOR (2018) IF: 1.894

Propofol Promotes Ankle Fracture Healing in Children by Inhibiting Inflammatory Response

DOI: 10.12659/MSM.908592
	Sample: Serum

Brazilian Journal of Psychiatry (2020) IF: 1.904

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments

DOI: 10.1590/1516-4446-2020-0908
PMID: 32556004	Sample: Serum

MEDICAL SCIENCE MONITOR (2020) IF: 1.918

Avicularin Reduces the Expression of Mediators of Inflammation and Oxidative Stress in Bradykinin-Treated MG-63 Human Osteoblastic Osteosarcoma Cells

DOI: 10.12659/MSM.921957
PMID: 32463805	Sample: Cell Culture Supernatant

ARCHIVES OF ORAL BIOLOGY (2020) IF: 1.931

Nec-1 attenuates inflammation and cytotoxicity induced by high glucose on THP-1 derived macrophages through RIP1

DOI: 10.1016/j.archoralbio.2020.104858
PMID: 32805637	Sample: Cell Culture Supernatant

Biology Open (2019) IF: 1.962

Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway

DOI: 10.1242/bio.043653
	Sample: L02 Cells

Evidence-based Complementary and Alternative Medicine (2019) IF: 1.984

In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera

DOI: 10.1155/2019/5961742
PMID: 30941196	Sample: Cell Culture Supernatant

HUMAN & EXPERIMENTAL TOXICOLOGY (2020) IF: 2.067

Investigation of DNA damage, oxidative stress, and inflammation in synthetic cannabinoid users:

DOI: 10.1177/0960327120930057
	Sample: Plasma

Molecular Medicine Reports (2020) IF: 2.1

Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway

DOI: 10.3892/mmr.2020.11739
PMID: 33300058	Sample: Cell Culture Supernatant

Trials (2021) IF: 2.279

Effect of Lycium barbarum polysaccharide supplementation in non-alcoholic fatty liver disease patients: study protocol for a randomized controlled trial

DOI: 10.1186/s13063-021-05529-6
PMID: 34521466	Sample: Blood

MOLECULAR BIOLOGY REPORTS (2022) IF: 2.316

NF-κB/ABCA1 pathway aggravates ox-LDL-induced cell pyroptosis by activation of NLRP3 inflammasomes in THP-1-derived macrophages

DOI: 10.1007/s11033-022-07408-y
PMID: 35579737	Sample: Thp-1 Monocytes

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021) IF: 2.352

Exploring potential serum levels of Homocysteine, interleukin-1 beta, and apolipoprotein B 48 as new biomarkers for patients with ischemic stroke

DOI: 10.1002/jcla.23996
PMID: 34492129	Sample: Serum

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2020) IF: 2.352

A case of asthma with Behcet’s disease: successful treatment with omalizumab and its effects on recurrent aphthous lesions

DOI: 10.1080/08923973.2020.1789656
	Sample: Serum

CHEMISTRY & BIODIVERSITY (2021) IF: 2.408

Total Flavonoids of Engelhardia roxburghiana Wall. Leaves Alleviated Foam Cells Formation through AKT/mTOR-Mediated Autophagy in the Progression of Atherosclerosis

DOI: 10.1002/cbdv.202100308
PMID: 34259387	Sample: Thp-1 Cell

BIOLOGICAL TRACE ELEMENT RESEARCH (2019) IF: 2.431

Study of Metal-Metal Interactions and Their Biomarkers Using an Intestinal Human Cell Line

DOI: 10.1007/s12011-019-01831-2
PMID: 31473895	Sample: Cell Lysate

Experimental and Therapeutic Medicine (2021) IF: 2.447

MicroRNA‑16 regulates lipopolysaccharide‑induced inflammatory factor expression by targeting TLR4 in normal human bronchial epithelial cells

DOI: 10.3892/etm.2021.10414
	Sample: Nhbe Cells

Experimental and Therapeutic Medicine (2021) IF: 2.447

Mangiferin inhibits hypoxia/reoxygenation‑induced alveolar epithelial cell injury via the SIRT1/AMPK signaling pathway

DOI: 10.3892/etm.2021.10654
	Sample: A549 Cell

International Journal of Rheumatic Diseases (2021) IF: 2.454

MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3

DOI: 10.1111/1756-185X.14089
PMID: 33650318	Sample: Cell Culture Supernatant(Thp-1)

DIGESTIVE DISEASES (2020) IF: 2.493

LncRNA PMS2L2 downregulates miR-24 through methylation to suppress cell apoptosis in ulcerative colitis

DOI: 10.1159/000513330
	Sample: Hcnepcs

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018) IF: 2.559

Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages

DOI: 10.1016/j.bbrc.2018.11.189
PMID: 30528233	Sample: Serum

Neuropsychiatric Disease and Treatment (2021) IF: 2.57

The Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke

DOI: 10.2147/NDT.S291164
PMID: 33727817	Sample: Serum

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2020) IF: 2.575

XIST silencing alleviated inflammation and mesangial cells proliferation in diabetic nephropathy by sponging miR-485

DOI: 10.1080/13813455.2020.1789880
PMID: 32669002	Sample: Serum

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2022) IF: 2.586

Upregulated NORAD is implicated in apoptosis, inflammation, and oxidative stress in ulcerative colitis through the nuclear factor-κappaB signaling

DOI: 10.1097/MEG.0000000000002370
PMID: 35412486	Sample: Human Normal Colonic Mucosal Cells (Fhcs)

Evidence-based Complementary and Alternative Medicine (2021) IF: 2.63

The Anti-Inflammatory Effect of Smilax china L. Extract on LPS-Stimulated THP-1 via Downregulation of MAPK and NF-κB Signaling Pathway

DOI: 10.1155/2021/9958808
	Sample: Thp-1 Cells

Evidence-based Complementary and Alternative Medicine (2022) IF: 2.63

Antiplatelet Activity of Tetramethylpyrazine via Regulation of the P2Y12 Receptor Downstream Signaling Pathway

DOI: 10.1155/2022/7941039
PMID: 35378909	Sample: Platelets Suspensions

GENE (2019) IF: 2.638

Downregulation of hsa_circ_0068087 ameliorates TLR4/NF-κB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in high glucose conditioned by sponging miR-197

DOI: 10.1016/j.gene.2019.05.012
	Sample: Human Umbilical Vein Endothelial Cells (Huvecs)

Journal of Healthcare Engineering (2022) IF: 2.682

Inhibition of microRNA-665 Alleviates Septic Acute Kidney Injury by Targeting Bcl-2

DOI: 10.1155/2022/2961187
PMID: 35281537	Sample: Hk-2 Cell

Food & Function (2016) IF: 2.686

Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats through regulation of intestinal permeability and microbiota

DOI: 10.1039/C6FO00831C
	Sample: Plasma,Serum

Journal of Applied Oral Science (2022) IF: 2.698

Granulocyte-macrophage colony-stimulating factor (GM-CSF) in subjects with different stages of periodontitis according to the new classification

DOI: 10.1590/1678-7757-2021-0423
PMID: 35262594	Sample: Gingival Crevicular Fluid (Gcf)

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019) IF: 2.705

Long non-coding RNA MEG3 regulates CSE-induced apoptosis and inflammation via regulating miR-218 in 16HBE cells

DOI: 10.1016/j.bbrc.2019.10.135
PMID: 31668807	Sample: Cell Culture Supernatant

BMC Oral Health (2021) IF: 2.757

The effect of conventional versus electronic cigarette use on treatment outcomes of peri-implant disease

DOI: 10.1186/s12903-021-01784-w
	Sample: Saliva

BIOMEDICINE & PHARMACOTHERAPY (2017) IF: 2.759

Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1–7) upregulation

DOI: 10.1016/j.biopha.2017.11.151
	Sample: Cell Culture Supernatant,Serum

EUROPEAN JOURNAL OF DERMATOLOGY (2022) IF: 2.805

Role of the long non-coding RNA, SPRR2C, based on an in vitro psoriatic keratinocyte cell model

DOI: 10.1684/ejd.2022.4247
PMID: 35866915	Sample: Ker-Ct Cell,Hacat Cell

BMC Molecular and Cell Biology (2022) IF: 2.813

Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs

DOI: 10.1186/s12860-022-00459-w
	Sample: Human Umbilical Vein Endothelial Cells (Huvecs)

BIOMEDICAL AND ENVIRONMENTAL SCIENCES (2022) IF: 2.831

Periodontal Ligament Stem Cells Reverse the High Glucose Level-Induced Inflammatory State of Macrophages

DOI: 10.3967/bes2022.089
PMID: 35945185	Sample: Thp-1 Cell

BMC Complementary Medicine and Therapies (2023) IF: 2.838

Exploration of the mechanism by which Huangqi Guizhi Wuwu decoction inhibits Lps-induced inflammation by regulating macrophage polarization based on network pharmacology

DOI: 10.1186/s12906-022-03826-4
	Sample: Human Histiocytic Lymphoma (U-937) Cell

Applied Sciences-Basel (2022) IF: 2.838

Effectiveness of a Cucumber Extract Supplement on Articular Pain in Patients with Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial

DOI: 10.3390/app13010485
	Sample: Plasma

NEPHRON (2021) IF: 2.847

XCL1 Aggravates Diabetic Nephropathy-Mediated Renal Glomerular Endothelial Cell Apoptosis and Inflammatory Response via Regulating p53/Nuclear Factor-Kappa B Pathway

DOI: 10.1159/000518172
PMID: 34518457	Sample: Hrgecs

Dermatologic Therapy (2021) IF: 2.851

Carotid intima-media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors

DOI: 10.1111/dth.14733
PMID: 33389789	Sample: Serum

MOLECULAR AND CELLULAR BIOCHEMISTRY (2019) IF: 2.884

Exogenous hydrogen sulfide mitigates LPS + ATP-induced inflammation by inhibiting NLRP3 inflammasome activation and promoting autophagy in L02 cells

DOI: 10.1007/s11010-019-03519-6
	Sample: Cell Culture Supernatant

INFLAMMATION (2019) IF: 2.939

Tacrolimus Inhibits TNF-α/IL-17A-Produced pro-Inflammatory Effect on Human Keratinocytes by Regulating IκBζ

DOI: 10.1007/s10753-019-01151-6
PMID: 31838663	Sample: Cell Culture Supernatant

NEUROTOXICITY RESEARCH (2020) IF: 2.992

The Neuroimmune and Neurotoxic Fingerprint of Major Neurocognitive Psychosis or Deficit Schizophrenia: a Supervised Machine Learning Study

DOI: 10.1007/s12640-019-00112-z
	Sample: Serum

PLANTA MEDICA (2022) IF: 3.007

Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury

DOI: 10.1055/a-1878-5704
	Sample: Thp-1 Cell

European Review for Medical and Pharmacological Sciences (2020) IF: 3.024

MiR-942-5p alleviates septic acute kidney injury by targeting FOXO3.

DOI: 10.26355/eurrev_202006_21521
	Sample: Cell Culture Supernatant

JOURNAL OF PERIODONTOLOGY (2017) IF: 3.03

Salivary Levels of NLRP3 Inflammasome‐Related Proteins as Potential Biomarkers of Periodontal Clinical Status

DOI: 10.1902/jop.2017.170244
	Sample: Saliva

NEUROCHEMICAL RESEARCH (2020) IF: 3.038

MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF-κB Signaling Pathway

DOI: 10.1007/s11064-020-02991-7
PMID: 32124161	Sample: Cell Culture Medium

NEUROSCIENCE LETTERS (2022) IF: 3.046

Role of CD36 rs1761667 AA genotype in the expression of inflammatory cytokines and Parkinson’s disease progression: A case-control study in a northern Han Chinese population

DOI: 10.1016/j.neulet.2022.136736
	Sample: Plasma

INFLAMMATION RESEARCH (2019) IF: 3.061

TNF-α/calreticulin dual signaling induced NLRP3 inflammasome activation associated with HuR nucleocytoplasmic shuttling in rheumatoid arthritis

DOI: 10.1007/s00011-019-01244-w
	Sample: Rheumatoid Arthritis (Ra) Fibroblast-Like Synovioc

INFLAMMATION RESEARCH (2019) IF: 3.061

Common variants of genes encoding TLR4 and TLR4 pathway members TIRAP and IRAK1 are effective on MCP1, IL6, IL1β, and TNFα levels in type 2 diabetes and insulin resistance

DOI: 10.1007/s00011-019-01263-7
	Sample: Serum

MOLECULAR IMMUNOLOGY (2019) IF: 3.064

Ventilator-induced lung injury is alleviated by inhibiting NLRP3 inflammasome activation

DOI: 10.1016/j.molimm.2019.03.011
PMID: 30952009	Sample: Plasma,Cell Culture Supernatant,Bronchoalveolar La

INTERNATIONAL IMMUNOPHARMACOLOGY (2018) IF: 3.118

S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway

DOI: 10.1016/j.intimp.2018.11.032
PMID: 30476824	Sample: Cell Culture Supernatant

INTERNATIONAL IMMUNOPHARMACOLOGY (2018) IF: 3.118

Novel anti-inflammatory target of geniposide: Inhibiting Itgβ1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts

DOI: 10.1016/j.intimp.2018.09.049
	Sample: Mh7A Cells

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022) IF: 3.124

Monocytes subtypes from pleural effusion reveal biomarker candidates for the diagnosis of tuberculosis and malignancy

DOI: 10.1002/jcla.24579
PMID: 35819097	Sample: Pleural Fluid

FISH & SHELLFISH IMMUNOLOGY (2018) IF: 3.185

Molecular characterization and functional analysis of MyD88 from the tropical sea cucumber, Holothuria leucospilota

DOI: 10.1016/j.fsi.2018.09.001
	Sample: Hek293T Cells

INFLAMMATION (2020) IF: 3.212

GPR120 Ameliorates Apoptosis and Inhibits the Production of Inflammatory Cytokines in Renal Tubular Epithelial Cells

DOI: 10.1007/s10753-020-01346-2
PMID: 33009637	Sample: Cell Culture Supernatant

MEDIATORS OF INFLAMMATION (2017) IF: 3.232

Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study

DOI: 10.1155/2017/3605350
	Sample: Serum

LIFE SCIENCES (2018) IF: 3.234

LncRNA PMS2L2 protects ATDC5 chondrocytes against lipopolysaccharide-induced inflammatory injury by sponging miR-203

DOI: 10.1016/j.lfs.2018.12.020
PMID: 30550887	Sample: Cell Culture Supernatant

Bioengineered (2021) IF: 3.269

N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK, AKT, ERK1/2, and

DOI: 10.1080/21655979.2021.1999550
	Sample: Beas-2B Cell

Bioengineered (2021) IF: 3.269

Knock-down of microRNA miR-556-5p increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via activating NLR family pyrin domain containing 3 (NLRP3)-mediated pyroptotic cell death

DOI: 10.1080/21655979.2021.1971502
PMID: 34488537	Sample: A549 Cell,H1299 Cell

Bioengineered (2022) IF: 3.269

Dihydroartemisinin targets fibroblast growth factor receptor 1 (FGFR1) to inhibit interleukin 17A (IL-17A)-induced hyperproliferation and inflammation of keratinocytes

DOI: 10.1080/21655979.2021.2021701
PMID: 35006038	Sample: Hacat Cell

Bioengineered (2022) IF: 3.269

Circ_0001897 regulates high glucose-induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-29c-3p/transforming growth factor beta 2 axis

DOI: 10.1080/21655979.2022.2070997
PMID: 35510503	Sample: Human Retinal Microvascular Endothelial Cell (Hrec

Bioengineered (2021) IF: 3.269

Carvedilol activates nuclear factor E2-related factor 2/ antioxidant response element pathway to inhibit oxidative stress and apoptosis of retinal pigment epithelial cells induced by high glucose

DOI: 10.1080/21655979.2021.2012627
PMID: 34898371	Sample: Arpe-19 Cell

CELLULAR IMMUNOLOGY (2019) IF: 3.291

DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway

DOI: 10.1016/j.cellimm.2019.103947
	Sample: Thp-1 Cells

FISH & SHELLFISH IMMUNOLOGY (2019) IF: 3.298

The first cloned echinoderm tumor necrosis factor receptor from Holothuria leucospilota: Molecular characterization and functional analysis

DOI: 10.1016/j.fsi.2019.08.008
PMID: 31394160	Sample: Cell Culture Supernatant

Clinical & Translational Oncology (2022) IF: 3.34

Cancer cell-derived exosomal LINC00313 induces M2 macrophage differentiation in non-small cell lung cancer

DOI: 10.1007/s12094-022-02907-7
PMID: 35980503	Sample: Thp-1 Cell,H1299 Cell

EXPERIMENTAL CELL RESEARCH (2020) IF: 3.383

iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin–angiotensin system-mediated congenital ureteropelvic junction obstruction

DOI: 10.1016/j.yexcr.2020.112086
	Sample: Serum,Cell Sample

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2021) IF: 3.402

Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced injury in human tubule epithelial cells by regulating miR-93-5p/TXNIP axis

DOI: 10.1007/s00430-021-00705-6
PMID: 33885954	Sample: Cell Culture Supernatant

Journal of Medical Biochemistry (2022) IF: 3.402

Cul4a attenuates LPS-induced acute kidney injury via blocking NF-kB signaling pathway in sepsis

DOI: 10.5937/jomb0-33096
	Sample: Hk-2 Cell

Biomed Research International (2020) IF: 3.411

CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis

DOI: 10.1155/2020/5341247
	Sample: Serum

JOURNAL OF ETHNOPHARMACOLOGY (2019) IF: 3.414

Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway

DOI: 10.1016/j.jep.2019.112361
PMID: 31683033	Sample: Cell Culture Supernatant

JOURNAL OF ETHNOPHARMACOLOGY (2019) IF: 3.414

Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology

DOI: 10.1016/j.jep.2019.112433
PMID: 31783135	Sample: Cell Culture Supernatant

Frontiers in Pediatrics (2022) IF: 3.418

Hyperoxia Induced Bronchopulmonary Dysplasia-Like Inflammation via miR34a-TNIP2-IL-1β Pathway

DOI: 10.3389/fped.2022.805860
	Sample: Sputum

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020) IF: 3.437

Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome

DOI: 10.1111/jgh.14961
PMID: 31860730	Sample: Serum,Tissue Homogenate

JOURNAL OF CELLULAR BIOCHEMISTRY (2019) IF: 3.448

Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast‐like synoviocytes through AKT/FOXO1 signaling

DOI: 10.1002/jcb.28724
	Sample: Rheumatoid Arthritis (Ra) Fibroblast-Like Synovioc

EXPERIMENTAL EYE RESEARCH (2021) IF: 3.467

Wedelolactone ameliorates Pseudomonas aeruginosa-induced inflammation and corneal injury by suppressing caspase-4/5/11/GSDMD-mediated non-canonical pyroptosis

DOI: 10.1016/j.exer.2021.108750
PMID: 34481822	Sample: Pihcks

JOURNAL OF NEUROIMMUNOLOGY (2022) IF: 3.478

Association between pro-inflammatory cytokines in cerebrospinal fluid and headache in patients with aneurysmal subarachnoid hemorrhage

DOI: 10.1016/j.jneuroim.2022.577841
PMID: 35279426	Sample: Cerebrospinal Fluid (Csf)

MEDIATORS OF INFLAMMATION (2018) IF: 3.549

Increased Expression of TLR10 in B Cell Subsets Correlates with Disease Activity in Rheumatoid Arthritis

DOI: 10.1155/2018/9372436
	Sample: Serum

Nanoscale Research Letters (2020) IF: 3.578

Nec-1 Attenuates Neurotoxicity Induced by Titanium Dioxide Nanomaterials on Sh-Sy5y Cells Through RIP1

DOI: 10.1186/s11671-020-03300-5
	Sample: Sh-Sy5Y Cell

Clinical Oral Investigations (2022) IF: 3.606

Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis

DOI: 10.1007/s00784-022-04681-w
PMID: 35986791	Sample: Gingival Crevicular Fluid (Gcf)

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021) IF: 3.652

Proanthocyanidins attenuate the high glucose-induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome

DOI: 10.1002/jbt.22845
PMID: 34338401	Sample: Arpe-19 Cell

BMC Complementary and Alternative Medicine (2021) IF: 3.659

Myrtenal and β-caryophyllene oxide screened from Liquidambaris Fructus suppress NLRP3 inflammasome components in rheumatoid arthritis

DOI: 10.1186/s12906-021-03410-2
PMID: 34583676	Sample: Serum,Ra-Fls

APOPTOSIS (2015) IF: 3.685

strain FP10

DOI: 10.1007/s10495-015-1162-9
	Sample: Cell Culture Supernatant

JOURNAL OF ETHNOPHARMACOLOGY (2020) IF: 3.69

Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways

DOI: 10.1016/j.jep.2020.113039
PMID: 32497675	Sample: Serum,Cell Culture Supernatant

BIOMEDICINE & PHARMACOTHERAPY (2019) IF: 3.743

Sapylin (OK-432) alters inflammation and angiogenesis in vivo and vitro

DOI: 10.1016/j.biopha.2019.108706
PMID: 30844656	Sample: Wound Drainage Fluid

INFLAMMOPHARMACOLOGY (2019) IF: 3.838

Tocilizumab attenuates acute lung and kidney injuries and improves survival in a rat model of sepsis via down-regulation of NF-κB/JNK: a possible role of P-glycoprotein

DOI: 10.1007/s10787-019-00628-y
PMID: 31440860	Sample: Serum

BIOSCIENCE REPORTS (2019) IF: 3.84

Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production

DOI: 10.1042/BSR20191252
PMID: 31651935	Sample: Serum,Plasma,Cell Sample

JOURNAL OF AFFECTIVE DISORDERS (2020) IF: 3.892

Construction of an exposure-pathway-phenotype in children with depression due to transfusion-dependent thalassemia: Results of (un)supervised machine learning.

DOI: 10.1016/j.jad.2020.12.089
	Sample: Serum

Annals of Translational Medicine (2021) IF: 3.932

Effect and mechanism of phospholipid scramblase 4 (PLSCR4) on lipopolysaccharide (LPS)-induced injury to human pulmonary microvascular endothelial cells

DOI: 10.21037/atm-20-7983
PMID: 33569461	Sample: Hpmecs

Annals of Translational Medicine (2022) IF: 3.932

Advanced platelet-rich fibrin promotes the paracrine function and proliferation of adipose-derived stem cells and contributes to micro-autologous fat transplantation by modulating HIF-1α and VEGF

DOI: 10.21037/atm-21-6812
	Sample: Adipose-Derived Stem Cell (Ascs)

INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943

Mammalian Ste20-like kinase 4 inhibits the inflammatory response in Aspergillus fumigatus keratitis

DOI: 10.1016/j.intimp.2020.107021
PMID: 33182037	Sample: Cell Lysate

INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943

Inhibition of HMGB1 involved in the protective of salidroside on liver injury in diabetes mice

DOI: 10.1016/j.intimp.2020.106987
PMID: 33217691	Sample: Cell Culture Supernatant

INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943

IL-38 alleviates the inflammatory response and the degeneration of nucleus pulposus cells via inhibition of the NF-κB signaling pathway in vitro

DOI: 10.1016/j.intimp.2020.106592
PMID: 32502922	Sample: Cell Culture Supernatant

JOURNAL OF PERIODONTAL RESEARCH (2022) IF: 3.946

Asymmetric and symmetric dimethylarginine gingival crevicular fluid levels in periodontitis

DOI: 10.1111/jre.13087
	Sample: Gingival Crevicular Fluid(Gcf)

NEUROCHEMICAL RESEARCH (2021) IF: 3.996

Silencing of UCA1 Protects Against MPP+-Induced Cytotoxicity in SK-N-SH Cells via Modulating KCTD20 Expression by Sponging miR-423-5p

DOI: 10.1007/s11064-020-03214-9
	Sample: Cell Culture Supernatant

Scientific Reports (2020) IF: 3.998

Validation of Salivary Markers, IL-1β, IL-8 and Lgals3bp for Detection of Oral Squamous Cell Carcinoma in an Indian Population

DOI: 10.1038/s41598-020-64494-3
	Sample: Saliva

Scientific Reports (2020) IF: 3.998

Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits

DOI: 10.1038/s41598-020-68543-9
PMID: 32669704	Sample: Cell Culture Supernatant

Pediatric Obesity (2021) IF: 4

The effects of Mediterranean diet on hepatic steatosis, oxidative stress, and inflammation in adolescents with non-alcoholic fatty liver disease: A randomized controlled trial

DOI: 10.1111/ijpo.12872
PMID: 34881510	Sample: Serum

American Journal of Translational Research (2021) IF: 4.06

Effect of levetiracetam in combination with topiramate on immune function, cognitive function, and neuronal nutritional status of children with intractable epilepsy


PMID: 34650715	Sample: Serum

INFLAMMATION (2022) IF: 4.092

LncRNA FLG-AS1 Mitigates Diabetic Retinopathy by Regulating Retinal Epithelial Cell Inflammation, Oxidative Stress, and Apoptosis via miR-380-3p/SOCS6 Axis

DOI: 10.1007/s10753-022-01665-6
PMID: 35461393	Sample: Arpe-19 Cell

ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119

LncRNA MEG3 ameliorates NiO nanoparticles-induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway

DOI: 10.1002/tox.23464
PMID: 35006638	Sample: A549 Cell

Drug Design Development and Therapy (2021) IF: 4.162

Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling

DOI: 10.2147/DDDT.S325814
PMID: 34764638	Sample: Nthy-Ori 3–1 Cells

Frontiers in Pharmacology (2020) IF: 4.225

Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Atractylodes macrocephala Koidz. for the Treatment of Chronic Gastritis

DOI: 10.3389/fphar.2019.01629
PMID: 32063848	Sample: Cell Culture Supernatant

SAUDI PHARMACEUTICAL JOURNAL (2021) IF: 4.33

Impact of Docosahexaenoic acid supplementation on proinflammatory cytokines release and the development of Necrotizing enterocolitis in preterm Neonates: A randomized controlled study

DOI: 10.1016/j.jsps.2021.09.012
PMID: 34819793	Sample: Blood

Epigenomics (2023) IF: 4.357

Low-dose 5-aza-2′-deoxycytidine protects against early renal injury by increasing klotho expression

DOI: 10.2217/epi-2022-0430
	Sample: Serum,Hk-2 Cell

PLoS Neglected Tropical Diseases (2021) IF: 4.411

Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion

DOI: 10.1371/journal.pntd.0009508
PMID: 34237073	Sample: Pleural Fluid

EUROPEAN JOURNAL OF PHARMACOLOGY (2019) IF: 4.432

Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs

DOI: 10.1016/j.ejphar.2019.172797
	Sample: Huvecs Cells

CELL BIOLOGY INTERNATIONAL (2023) IF: 4.473

TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation

DOI: 10.1002/cbin.12002
	Sample: Human Retinal Capillary Endothelial Cells (Hrcecs)

BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545

Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis

DOI: 10.1016/j.biopha.2020.110326
	Sample: Cell Culture Supernatant

BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545

LncRNA SNHG5 regulates cell apoptosis and inflammation by miR-132/PTEN axis in COPD

DOI: 10.1016/j.biopha.2020.110016
PMID: 32145584	Sample: Cell Culture Supernatant

INFLAMMATION RESEARCH (2021) IF: 4.575

S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1

DOI: 10.1007/s00011-021-01489-4
PMID: 34459932	Sample: Hrec

FISH & SHELLFISH IMMUNOLOGY (2020) IF: 4.581

Molecular characterization, inducible expression and functional analysis of an IKKβ from the tropical sea cucumber Holothuria leucospilota

DOI: 10.1016/j.fsi.2020.06.024
PMID: 32585358	Sample: Cell Culture Supernatant

Oxidative Medicine and Cellular Longevity (2017) IF: 4.593

ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages

DOI: 10.1155/2017/8519169
	Sample: Cell Culture Supernatant

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016) IF: 4.638

Melatonin effects on myocardial ischemia–reperfusion injury: Impact on the outcome in patients undergoing coronary artery bypass grafting surgery

DOI: 10.1016/j.ijcard.2016.07.108
	Sample: Plasma

JOURNAL OF PSYCHIATRIC RESEARCH (2022) IF: 4.791

Comparison of cognitive impairments with lipid profiles and inflammatory biomarkers in unipolar and bipolar depression

DOI: 10.1016/j.jpsychires.2022.04.002
PMID: 35429740	Sample: Serum

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021) IF: 4.799

The Role of SREC-Ⅰ in Innate Immunity to Aspergillus fumigatus Keratitis

DOI: 10.1167/iovs.62.9.12
PMID: 34236384	Sample: Hcecs Cells

Journal of Immunology Research (2021) IF: 4.818

Remote Inflammatory Preconditioning Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Intrinsic Apoptosis in Rats

DOI: 10.1155/2021/1125199
PMID: 34595242	Sample: Serum

Journal of Immunology Research (2021) IF: 4.818

Moesin Is a Novel Biomarker of Endothelial Injury in Sepsis

DOI: 10.1155/2021/6695679
PMID: 33628853	Sample: Cell Culture Supernatant(Hmecs)

Aging-US (2020) IF: 4.831

In situ self-assembly of Au-antimiR-155 nanocomplexes mediates TLR3-dependent apoptosis in hepatocellular carcinoma cells.

DOI: 10.18632/aging.103799
	Sample: Cell Culture Medium

MOLECULES (2022) IF: 4.927

Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide

DOI: 10.3390/molecules27134264
PMID: 35807509	Sample: Human Fibroblast Cell

INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932

Isoliquiritigenin alleviates P. gingivalis-LPS/ATP-induced pyroptosis by inhibiting NF-κB/ NLRP3/GSDMD signals in human gingival fibroblasts

DOI: 10.1016/j.intimp.2021.108338
PMID: 34794890	Sample: Hgfs Cells

INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932

Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts

DOI: 10.1016/j.intimp.2021.107456
PMID: 33588175	Sample: Cell Culture Supernatant

INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 4.932

Chlorogenic acid attenuates inflammation in LPS-induced Human gingival fibroblasts via CysLT1R/Nrf2/NLRP3 signaling

DOI: 10.1016/j.intimp.2022.108706
PMID: 35313270	Sample: Human Gingival Fibroblasts (Hgfs)

JOURNAL OF LEUKOCYTE BIOLOGY (2022) IF: 4.962

Periodontal ligament stem cells promote polarization of M2 macrophages

DOI: 10.1002/JLB.1MA1220-853RR
PMID: 34982483	Sample: Thp-1 Cell

PPAR Research (2019) IF: 4.964

Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR- Functional Module of Autophagy in Rheumatoid Arthritis

DOI: 10.1155/2019/6403504
	Sample: Rheumatoid Arthritis (Ra) Fibroblast-Like Synovioc

Advanced Therapeutics (2022) IF: 5.003

Fructose-coated Ångstrom silver particles suppress gastric cancer growth by activating gasdermin D-mediated pyroptosis

DOI: 10.1002/adtp.202200100
	Sample: Bgc-823 Cell,Sgc-7901 Cells

LIFE SCIENCES (2022) IF: 5.037

STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-κB/HIF-1α pathway

DOI: 10.1016/j.lfs.2021.120089
PMID: 35007563	Sample: Arpe-19 Cell

CELL PROLIFERATION (2019) IF: 5.039

Inhibition of CREB‐mediated ZO‐1 and activation of NF‐κB‐induced IL‐6 by colonic epithelial MCT4 destroys intestinal barrier function

DOI: 10.1111/cpr.12673
	Sample: Caco2 Cells，Ht‐29 Cell

Journal of Functional Foods (2022) IF: 5.223

High fiber multigrain supplementation improved disease activity score, circulating inflammatory and oxidative stress biomarkers in rheumatoid arthritis (RA) patients: A randomized human clinical trial

DOI: 10.1016/j.jff.2022.105392
	Sample: Blood

Frontiers in Cellular and Infection Microbiology (2021) IF: 5.293

GLUT3 as an Intersection of Glycerophospholipid Metabolism and the Innate Immune Response to Candida albicans

DOI: 10.3389/fcimb.2021.648988
	Sample: Thp-1 Cells

Food & Function (2022) IF: 5.396

A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of gut microbiota and relief from chronic constipation

DOI: 10.1039/D1FO03896F
	Sample: Serum

BRITISH JOURNAL OF PHARMACOLOGY (2017) IF: 5.491

The TIR/BB‐loop mimetic AS‐1 prevents non‐alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3‐ASC inflammasome activation

DOI: 10.1111/bph.13786
	Sample: Cell Culture Supernatant

Molecular Therapy-Nucleic Acids (2018) IF: 5.66

miR-93-5p-Containing Exosomes Treatment Attenuates Acute Myocardial Infarction-Induced Myocardial Damage

DOI: 10.1016/j.omtn.2018.01.010
	Sample: Serum

Aging-US (2022) IF: 5.682

The TLR4/NF-κB/MAGI-2 signaling pathway mediates postoperative delirium

DOI: 10.18632/aging.203955
	Sample: Plasma,Cerebrospinal Fluid

MOLECULAR NEUROBIOLOGY (2022) IF: 5.682

Acrylamide Induces Neurotoxicity in SH-SY5Y Cells via NLRP3-mediated Pyroptosis

DOI: 10.1007/s12035-022-03098-6

Cell Communication and Signaling (2022) IF: 5.712

The ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells

DOI: 10.1186/s12964-022-00879-3
PMID: 35551614	Sample: A549 Cell

INTERNATIONAL IMMUNOPHARMACOLOGY (2023) IF: 5.714

Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats

DOI: 10.1016/j.intimp.2022.109659
	Sample: Caco-2 Cell

INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 5.714

CircVAPA contributes to hyper-proliferation and inflammation of keratinocytes through miR-125b-5p/sirt6 axis in psoriasis

DOI: 10.1016/j.intimp.2022.109632
	Sample: Hacat Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208

Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo

DOI: 10.3390/ijms232416134
	Sample: Thp-1 Cells

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021) IF: 6.291

Novel insights into the role of BRD4 in fine particulate matter induced airway hyperresponsiveness

DOI: 10.1016/j.ecoenv.2021.112440
PMID: 34175826	Sample: Hasmcs Cells

PHYTOTHERAPY RESEARCH (2022) IF: 6.388

Atractylodin targets GLA to regulate D-mannose metabolism to inhibit osteogenic differentiation of human valve interstitial cells and ameliorate aortic valve calcification

DOI: 10.1002/ptr.7628
PMID: 36199227	Sample: Hvics

ENVIRONMENTAL RESEARCH (2021) IF: 6.498

Changes in genotoxicity, inflammatory and oxidative stress parameters of workers in marble processing plants

DOI: 10.1016/j.envres.2021.111209
PMID: 33895109	Sample: Plasma

Pharmaceutics (2022) IF: 6.525

In Vitro Antibacterial and Anti-Inflammatory Activity of Arctostaphylos uva-ursi Leaf Extract against Cutibacterium acnes

DOI: 10.3390/pharmaceutics14091952
PMID: 36145700	Sample: Hacat Cell

Oxidative Medicine and Cellular Longevity (2022) IF: 6.543

Silencing ATF3 Might Delay TBHP-Induced Intervertebral Disc Degeneration by Repressing NPC Ferroptosis, Apoptosis, and ECM Degradation

DOI: 10.1155/2022/4235126
PMID: 35480873	Sample: Npcs

Oxidative Medicine and Cellular Longevity (2022) IF: 6.543

DNA Methyltransferase 3b Accelerates the Process of Atherosclerosis

DOI: 10.1155/2022/5249367
PMID: 35422896	Sample: Tregs

Oxidative Medicine and Cellular Longevity (2022) IF: 6.543

Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration

DOI: 10.1155/2022/2776440
PMID: 35039758	Sample: Nucleus Pulposus Cell (Npcs)

Oxidative Medicine and Cellular Longevity (2021) IF: 6.543

Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo

DOI: 10.1155/2021/5584447
PMID: 34239691	Sample: Np Cells

Cancers (2023) IF: 6.575

Salivary Interleukin Levels in Oral Squamous Cell Carcinoma and Oral Epithelial Dysplasia: Findings from a Sri Lankan Study

DOI: 10.3390/cancers15051510
	Sample: Saliva

Frontiers in Cell and Developmental Biology (2021) IF: 6.684

Fexofenadine Protects Against Intervertebral Disc Degeneration Through TNF Signaling

DOI: 10.3389/fcell.2021.687024
	Sample: Np Cell

Frontiers in Cell and Developmental Biology (2021) IF: 6.684

Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration

DOI: 10.3389/fcell.2021.672847
PMID: 34239872	Sample: Np Cells

Nutrients (2022) IF: 6.706

CCN1/Integrin α5β1 Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation

DOI: 10.3390/nu14183871
	Sample: Lo2 Hepatocytes

Nutrients (2022) IF: 6.706

Alteration in Gut Microbiota Associated with Zinc Deficiency in School-Age Children

DOI: 10.3390/nu14142895
PMID: 35889856	Sample: Serum

Journal of Inflammation Research (2021) IF: 6.922

Silenced SNHG1 Inhibited Epithelial-Mesenchymal Transition and Inflammatory Response of ARPE-19 Cells Induced by High Glucose

DOI: 10.2147/JIR.S299010
	Sample: Arpe-19 Cell

Journal of Inflammation Research (2022) IF: 6.922

Long Noncoding RNA MIAT Regulates Hyperosmotic Stress-Induced Corneal Epithelial Cell Injury via Inhibiting the Caspase-1-Dependent Pyroptosis and Apoptosis in Dry Eye Disease

DOI: 10.2147/JIR.S361541
PMID: 35676970	Sample: Human Corneal Epithelial Cell (Hcecs)

Journal of Inflammation Research (2021) IF: 6.922

Anti-Inflammatory Effects of Four Psilocybin-Containing Magic Mushroom Water Extracts in vitro on 15-Lipoxygenase Activity and on Lipopolysaccharide-Induced Cyclooxygenase-2 and Inflammatory Cytokines in Human U937 Macrophage Cells

DOI: 10.2147/JIR.S317182
	Sample: U937 Cell

JOURNAL OF PERIODONTOLOGY (2021) IF: 6.993

Periodontitis activates the NLRP3 inflammasome in serum and saliva

DOI: 10.1002/JPER.21-0049
PMID: 34008185	Sample: Serum

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022) IF: 7.129

Autophagy promotes GSDME-mediated pyroptosis via intrinsic and extrinsic apoptotic pathways in cobalt chloride-induced hypoxia reoxygenation-acute kidney injury

DOI: 10.1016/j.ecoenv.2022.113881
PMID: 35863214	Sample: Hk-2 Cell

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2023) IF: 7.129

Acute liver injury induced by carbon tetrachloride reversal by Gandankang aqueous extracts through nuclear factor erythroid 2-related factor 2 signaling pathway

DOI: 10.1016/j.ecoenv.2023.114527
	Sample: Hepg2 Cell

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020) IF: 7.143

MicroRNA-101-3p Downregulates TLR2 Expression, Leading to Reduction in Cytokine Production by Treponema pallidum–Stimulated Macrophages

DOI: 10.1016/j.jid.2019.12.012
	Sample: Plasma,Thp-1 Cell

CARBOHYDRATE POLYMERS (2020) IF: 7.182

The effect of doxycycline-containing chitosan/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease

DOI: 10.1016/j.carbpol.2020.116163
PMID: 32241426	Sample: Gingival Crevicular Fluid

BRAIN BEHAVIOR AND IMMUNITY (2021) IF: 7.217

Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial

DOI: 10.1016/j.bbi.2021.11.023
PMID: 34875345	Sample: Serum

Oxidative Medicine and Cellular Longevity (2022) IF: 7.31

Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury

DOI: 10.1155/2022/3576892
PMID: 35855864	Sample: Serum

FOOD RESEARCH INTERNATIONAL (2022) IF: 7.425

N-3 polyunsaturated fatty acids protect esophageal epithelial cells from acid exposure

DOI: 10.1016/j.foodres.2022.111943
PMID: 36461199	Sample: Het-1A Cell

Frontiers in Immunology (2022) IF: 7.561

TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma.

DOI: 10.3389/fimmu.2022.883885
	Sample: Thp-1 Monocytes

Cells (2022) IF: 7.666

Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis

DOI: 10.3390/cells11233836

Cell Reports (2020) IF: 8.109

Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis

DOI: 10.1016/j.celrep.2020.107990
PMID: 32755583	Sample: Plasma

Cell Death & Disease (2021) IF: 8.469

Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site

DOI: 10.1038/s41419-020-03317-9
PMID: 33431796	Sample: Serum,Cell Culture Supernatant

CANCER LETTERS (2022) IF: 8.679

Decreased CXCR2 expression on circulating monocytes of colorectal cancer impairs recruitment and induces Re-education of tumor-associated macrophages

DOI: 10.1016/j.canlet.2022.01.004
PMID: 34999169	Sample: Serum,Thp-1 Cell,Human Circulating Cd14+ Monocytes

EXPERIMENTAL AND MOLECULAR MEDICINE (2019) IF: 8.718

Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc

DOI: 10.1038/s12276-019-0310-7
	Sample: Np Cells

EXPERIMENTAL AND MOLECULAR MEDICINE (2022) IF: 8.718

Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

DOI: 10.1038/s12276-022-00729-9
PMID: 35145201	Sample: Nucleus Pulposus (Np) Cell

Frontiers in Immunology (2022) IF: 8.786

METTL3 inhibits inflammation of retinal pigment epithelium cells by regulating NR2F1 in an m6A-dependent manner

DOI: 10.3389/fimmu.2022.905211
PMID: 35936005	Sample: Rpe Cell

Molecular Therapy-Nucleic Acids (2021) IF: 8.886

Enhancer RNA lnc-CES1-1 inhibits decidual cell migration by interacting with RNA-binding protein FUS and activating PPARγ in URPL

DOI: 10.1016/j.omtn.2021.02.018
PMID: 33738142	Sample: Cell Culture Supernatant(Htr-8/Svneo Cells,Jeg-3 C

Journal of Neuroinflammation (2022) IF: 9.587

Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro

DOI: 10.1186/s12974-022-02535-6
PMID: 35768823	Sample: Cerebrospinal Fluid (Csf),Peripheral Monocytes

ENVIRONMENTAL POLLUTION (2022) IF: 9.988

Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line

DOI: 10.1016/j.envpol.2022.120217
PMID: 36155221	Sample: Hmc3 Cell

JOURNAL OF NANOBIOTECHNOLOGY (2022) IF: 10.435

Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

DOI: 10.1186/s12951-022-01288-x
PMID: 35248068	Sample: Serum

JOURNAL OF PINEAL RESEARCH (2023) IF: 12.081

Melatonin inhibits atherosclerosis progression via Galectin-3 downregulation to enhance autophagy and inhibit inflammation

DOI: 10.1111/jpi.12855
	Sample: Serum

MOLECULAR PSYCHIATRY (2020) IF: 12.384

LncRNA- AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia

DOI: 10.1038/s41380-020-0662-3
	Sample: Serum

HEPATOLOGY (2020) IF: 17.425

Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD

DOI: 10.1002/hep.31056
PMID: 31808577	Sample: Serum

CELL (2020) IF: 38.637

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

DOI: 10.1016/j.cell.2020.08.009
PMID: 33015716	Sample: Cell Culture Medium

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