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Recombinant Human ACE2 Protein (His Tag)

  • Cat.No.:PKSH032068

  • Expression host: HEK293 Cells

To Purchase PKSH032068

  • 10μg
  • 50μg
Price: $223


Synonyms Angiotensin-Converting Enzyme 2;ACE-Related Carboxypeptidase;Angiotensin-Converting Enzyme Homolog;ACEH;Metalloprotease MPROT15;ACE2
Species Human
Expression_host HEK293 Cells
Sequence Gln18-Ser740
Accession Q9BYF1
Mol_Mass 84.6 kDa
AP_Mol_Mass 103 kDa
Tag C-His
Bio_Activity Loaded 2019-nCoV S Protein RBD-mFc on AMC Biosensor, can bind Human ACE-2-His with an affinity constant of 2.06 nM as determined in BLI assay.


Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
Reconstitution Not Applicable


Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.


  1. Viruses-Basel (2022) IF: 5.818
    Design of Three Residues Peptides against SARS-CoV-2 Infection

    DOI: 10.3390/v14102103

    PMID: 36298659


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