Synonyms	Fibrinogen-like protein 1;FGL1;HP-041;Hepassocin;HFREP-1;LFIRE-1
Species	Human
Expression_host	HEK293 Cells
Sequence	Leu23-Ile312
Accession	Q08830
Application	Functional ELISA
Mol_Mass	60.6 kDa
AP_Mol_Mass	60-65 kDa
Tag	C-mFc
Bio_Activity	Immobilized Human LAG-3(Cat: PKSH033596) at 5μg/ml(100 μl/well) can bind Human FGL1-Fc. The ED₅₀ of Human FGL1-Fc is 30-90 ng/ml.

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Hepassocin; also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1); is a liver-specific secreted protein belonging to the fibronogen superfamily; whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .

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