Synonyms	ACPL;CD218b;CDw218b;IL-18R-beta;IL-18RAcP;IL-18Rbeta;IL-1R-7;IL-1R7;IL-1RAcPL;IL18RB
Species	Human
Expression_host	HEK293 Cells
Sequence	Phe20-Arg356
Accession	O95256
Mol_Mass	39.4 kDa
AP_Mol_Mass	56 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution	Please refer to the printed manual for detailed information.

Background

IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease.

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