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T(Testosterone) ELISA Kit

Citations(178)

  • Cat.No.:E-EL-0155

  • Reactivity: Universal
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Manual MSDS

To Purchase E-EL-0155

Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $495
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Product Details

Properties

Assay type Competitive-ELISA
Format 96T/48T/24
Assay time 2.0h
Detection range 0.31-20 ng/mL
Sensitivity 0.17 ng/mL
Sample type &Sample volume serum, plasma, urine, saliva; 50μL
Specificity This kit recognizes T in samples. No significant cross-reactivity or interference between T and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of T concentrations in serum, plasma, urine, saliva.

Test Principle

This ELISA kit uses the Competitive-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with T. During the reaction, T in the sample or standard competes with a fixed amount of T on the solid phase supporter for sites on the Biotinylated Detection Ab specific to T. Excess conjugate and unbound sample or standard are washed away, and Avidin-Horseradish Peroxidase (HRP) conjugate are added to each micro plate well and incubated. Then a TMB substrate solution is added to each well. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns from blue to yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The concentration of T in tested samples can be calculated by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips 		-20℃, 12 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL 		-20℃(Protect from light), 12 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 12 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8℃
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level T were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level T were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (ng/mL) 1.33 5.22 10.88 1.54 5.73 10.02
Standard deviation 0.11 0.35 0.46 0.14 0.35 0.68
CV (%) 8.13 6.72 4.27 9.23 6.18 6.75

Recovery

The recovery of T spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 80-90 84
EDTA plasma(n=8) 82-94 87
Urine(n=8) 85-102 95

Linearity

Samples were spiked with high concentrations of T and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Assay Procedures

elisa assay procedure 1

1. Add 50μL standard or sample to the wells, immediately add 50μL Biotinylated Detection Ab working solution to each well. Incubate for 45 min at 37°C
elisa assay procedure 2

2. Aspirate and wash the plate for 3 times
elisa assay procedure 3

3. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times
elisa assay procedure 4

4. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C
elisa assay procedure 5

5. Add 50μL Stop Solution
elisa assay procedure 6

6. Read the plate at 450nm immediately. Calculation of the results

Citations

  1. Frontiers in Pharmacology (2022) IF: 5.811
    Proteomic Study on the Reproductive Toxicity of Tripterygium Glycosides in Rats

    DOI: 10.3389/fphar.2022.888968

    PMID: 35668950

    		 Sample: Serum
  2. BIOORGANIC CHEMISTRY (2020) IF: 4.831
    Two resveratrol analogs, pinosylvin and 4,4′-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway

    DOI: 10.1016/j.bioorg.2020.104295
    Sample: Serum
  3. Frontiers in Pharmacology (2021) IF: 5.811
    Edible Bird’s Nest Supplementation Improves Male Reproductive Parameters of Sprague Dawley Rat

    DOI: 10.3389/fphar.2021.631402
    Sample: Serum
  4. JOURNAL OF MOLECULAR ENDOCRINOLOGY (2021) IF: 5.098
    Pathological changes and oxidative stress of the HPG axis in hypothyroid rat

    DOI: 10.1530/JME-21-0095

    PMID: 34270447

    		 Sample: Serum
  5. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017) IF: 5.104
    Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR

    DOI: 10.1159/000457881
    Sample: Serum
  6. Frontiers in Pharmacology (2022) IF: 5.988
    Andrographolide exerted anti-inflammatory effects thereby reducing sex hormone synthesis in LPS-induced female rats, but had no effect on hormone production in healthy ones.

    DOI: 10.3389/fphar.2022.980064
    Sample: Serum
  7. Food Science and Human Wellness (2022) IF: 5.154
    The protective effects of Procyanidin C-1 on bisphenol a-induced testicular dysfunction in aged mice

    DOI: 10.1016/j.fshw.2022.03.020
    Sample: Serum
  8. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022) IF: 5.19
    Dietary myricetin assuages atrazine-mediated hypothalamic-pituitary–testicular axis dysfunction in rats

    DOI: 10.1007/s11356-022-23033-5
    Sample: Serum,Intra-Testicular
  9. EUROPEAN JOURNAL OF PHARMACOLOGY (2022) IF: 5.195
    Insights into the role of pERK1/2 signaling in post-cerebral ischemia reperfusion sexual dysfunction in rats

    DOI: 10.1016/j.ejphar.2022.175258

    PMID: 36096157

    		 Sample: Serum
  10. CLINICAL SCIENCE (2018) IF: 5.22
    CTRP3 attenuates high-fat diet-induced male reproductive dysfunction in mice

    DOI: 10.1042/CS20180179
    Sample: Serum
  11. Heliyon (2021)
    Treatment with acetate during late pregnancy protects dams against testosterone-induced renal dysfunction

    DOI: 10.1016/j.heliyon.2021.e05920
    Sample: Plasmsa
  12. Toxicology Reports (2021)
    Sildenafil augments fetal weight and placental adiponectin in gestational testosterone-induced glucose intolerant rats

    DOI: 10.1016/j.toxrep.2021.06.011
    Sample: Plasma，Placental
  13. Heliyon (2021)
    Sildenafil ameliorates leptin resistance and normalizes lipid handling in the hypothalamic and adipose tissues of testosterone-exposed pregnant rats

    DOI: 10.1016/j.heliyon.2021.e07574
    Sample: Plasma
  14. Veterinary World (2020)
    Black soybean tempeh and purple sweet potato improve sperm quality in streptozotocin-induced diabetic rats

    DOI: 10.14202/vetworld.2020.2534-2540
    Sample: Serum
  15. International Journal of Fertility & Sterility (2017)
    Aluminium-Induced Oxidative Stress, Apoptosis and Alterations in Testicular Tissue and Sperm Quality in Wistar Rats: Ameliorative Effects of Curcumin

    DOI: 10.22074/ijfs.2017.4859
    Sample: Plasma
  16. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2021) IF: 0.533
    Effect of total flavonoids of Cuscuta chinensis Lam. (Convolvulaceae) on oxidative stress injury in mouse testis and epididymis, and on serum levels of reproductive hormones in oligoasthenospermia mice model

    DOI: 10.4314/tjpr.v18i6.15
    Sample: Serum,Tissue Homogenate
  17. Romanian Journal of Morphology and Embryology (2021) IF: 1.033
    Carvacrol treatment opens Kir6.2 ATP-dependent potassium channels and prevents apoptosis on rat testis following ischemia–reperfusion injury model

    DOI: 10.47162/RJME.62.1.17
    Sample: Serum
  18. Experimental and Therapeutic Medicine (2018) IF: 1.41
    Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis

    DOI: 10.3892/etm.2017.5672
    Sample: Serum
  19. ZYGOTE (2021) IF: 1.442
    GPR120 agonist ameliorated insulin resistance and improved ovarian function

    DOI: 10.1017/S0967199421000873

    PMID: 34879886

    		 Sample: Serum
  20. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2015) IF: 1.562
    Brain thromboxane A2 via arachidonic acid cascade induces the hypothalamic–pituitary–gonadal axis activation in rats

    DOI: 10.1016/j.autneu.2015.02.005
    Sample: Plasma
  21. Systems Biology in Reproductive Medicine (2018) IF: 1.582
    Grape seed procyanidins extract attenuates Cisplatin-induced oxidative stress and testosterone synthase inhibition in rat testes

    DOI: 10.1080/19396368.2018.1450460
    Sample: Serum
  22. JOURNAL OF FOOD BIOCHEMISTRY (2020) IF: 1.662
    Ferulic acid influences Nrf2 activation to restore testicular tissue from cadmium‐induced oxidative challenge, inflammation, and apoptosis in rats

    DOI: 10.1111/jfbc.13505
    Sample: Serum,Tissue Homogenate
  23. JOURNAL OF FOOD BIOCHEMISTRY (2020) IF: 1.662
    Berberine mitigates oxidative damage associated with testicular impairment following mercury chloride intoxication

    DOI: 10.1111/jfbc.13385
    Sample: Tissue Homogenate
  24. Journal of Applied Biomedicine (2018) IF: 1.783
    Pre-pregnancy stress suppressed the reproductive systems in parents and changed sex ratio in offspring

    DOI: 10.1016/j.jab.2018.08.002
    Sample: Plasma
  25. Evidence-based Complementary and Alternative Medicine (2020) IF: 1.813
    Duzhong Butiansu Prescription Improves Heat Stress-Induced Spermatogenic Dysfunction by Regulating Sperm Formation and Heat Stress Pathway

    DOI: 10.1155/2020/6723204

    PMID: 32184896

    		 Sample: Serum
  26. ANDROLOGIA (2019) IF: 1.84
    High dose of standardised extract of Costus afer leaves potentiates cadmium reproductive toxicity in Wistar rats

    DOI: 10.1111/and.13360
    Sample: Plasma
  27. ANDROLOGIA (2019) IF: 1.84
    Effects of N‐nitro L‐arginine methyl ester and α‐tocopherol on testicular oxidative stress caused by exposure to cigarette smoke

    DOI: 10.1111/and.13355
    Sample: Serum
  28. ANDROLOGIA (2020) IF: 1.951
    Selenium attenuates diclofenac‐induced testicular and epididymal toxicity in rats

    DOI: 10.1111/and.13669
    Sample: Sperm
  29. HIGH ALTITUDE MEDICINE & BIOLOGY (2021) IF: 1.981
    Association Between 17β-Estradiol Receptors and Nitric Oxide Signaling Augments High-Altitude Adaptation of Ladakhi Highlanders

    DOI: 10.1089/ham.2020.0187
    Sample: Plasma
  30. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020) IF: 2.05
    Spironolactone reversed hepato-ovarian triglyceride accumulation caused by letrozole-induced polycystic ovarian syndrome: tissue uric acid—a familiar foe

    DOI: 10.1007/s00210-020-01809-1
    Sample: Plasma
  31. Reproductive Biology (2022) IF: 2.089
    ALG2 inhibits the epithelial-to-mesenchymal transition and stemness of ovarian granulosa cells through the Wnt/β-catenin signaling pathway in polycystic ovary syndrome

    DOI: 10.1016/j.repbio.2022.100706

    PMID: 36327672

    		 Sample: Serum
  32. International Journal of Environmental Research and Public Health (2017) IF: 2.101
    1950MHz Radio Frequency Electromagnetic Radiation Inhibits Testosterone Secretion of Mouse Leydig Cells

    DOI: 10.3390/ijerph15010017
    Sample: Tm3 Cell
  33. ANIMAL REPRODUCTION SCIENCE (2022) IF: 2.145
    Dietary carob fruit (Ceratonia siliqua L.) supplementation improves spermatogenesis, semen quality and embryonic death via antioxidant effect in aging broiler breeder roosters

    DOI: 10.1016/j.anireprosci.2022.106967

    PMID: 35299115

    		 Sample: Blood
  34. INTEGRATIVE CANCER THERAPIES (2020) IF: 2.379
    Ginkgo biloba Extract Attenuates Methotrexate-Induced Testicular Injury in Rats: Cross-talk Between Oxidative Stress, Inflammation, Apoptosis, and miRNA-29a Expression:

    DOI: 10.1177/1534735420969814
    Sample: Serum
  35. BIOLOGICAL TRACE ELEMENT RESEARCH (2019) IF: 2.431
    The Footprints of Oxidative Stress and Mitochondrial Impairment in Arsenic Trioxide-Induced Testosterone Release Suppression in Pubertal and Mature F1-Male Balb/c Mice via the Downregulation of 3β-HSD, 17β-HSD, and CYP11a Expression

    DOI: 10.1007/s12011-019-01815-2
    Sample: Serum,Tissue Homogenate
  36. Experimental and Therapeutic Medicine (2018) IF: 2.447
    Analysis of gene expression and functional changes of adrenal gland in a rat model of kidney yang deficiency syndrome treated with Sini decoction

    DOI: 10.3892/etm.2018.6521

    PMID: 30214533

    		 Sample: Serum
  37. International Journal of Environmental Research and Public Health (2019) IF: 2.468
    Effects of 220 MHz Pulsed Modulated Radiofrequency Field on the Sperm Quality in Rats

    DOI: 10.3390/ijerph16071286
    Sample: Serum
  38. Journal of Ovarian Research (2019) IF: 2.469
    Abnormal expression of HSP70 may contribute to PCOS pathology

    DOI: 10.1186/s13048-019-0548-7
    Sample: Serum
  39. BMC Complementary and Alternative Medicine (2019) IF: 2.479
    Cannabinoid-deficient Benin republic hemp ( Cannabis sativa L.) improves semen parameters by reducing prolactin and enhancing anti-oxidant status

    DOI: 10.1186/s12906-019-2541-5
    Sample: Plasma
  40. ENVIRONMENTAL TOXICOLOGY (2018) IF: 2.491
    Di‐(2‐ethylhexyl) phthalate (DEHP)‐induced testicular toxicity through Nrf2‐mediated Notch1 signaling pathway in Sprague–Dawley rats

    DOI: 10.1002/tox.22559
    Sample: Tissue Homogenate
  41. WATER AIR AND SOIL POLLUTION (2021) IF: 2.52
    Effects of Environmental-Related Concentration of Tamoxifen on Hormonal Balance and Reproduction of the Golden Apple Snail, Pomacea canaliculata (Caenogastropoda: Ampullariidae)

    DOI: 10.1007/s11270-021-05472-x
    Sample: Sexual Organ
  42. ANDROLOGIA (2022) IF: 2.532
    The impact of dolutegravir-based combination antiretroviral therapy on the spermatozoa and fertility parameters of men living with human immunodeficiency virus

    DOI: 10.1111/and.14621

    PMID: 36261884

    		 Sample: Serum
  43. Iranian Journal of Basic Medical Sciences (2023) IF: 2.532
    Inhibitory effects of Calocybe indica macrofungi on experimental benign prostatic hyperplasia in rats

    DOI: 10.22038/IJBMS.2022.64972.14309
    Sample: Serum
  44. Reproductive Sciences (2020) IF: 2.616
    Ascorbic Acid and Alpha-Tocopherol Contribute to the Therapy of Polycystic Ovarian Syndrome in Mouse Models

    DOI: 10.1007/s43032-020-00273-9

    PMID: 32725591

    		 Sample: Serum
  45. Evidence-based Complementary and Alternative Medicine (2021) IF: 2.63
    Effect of Electroacupuncture on Reproductive Disorders and Insulin Resistance in a Murine Polycystic Ovary Syndrome Model

    DOI: 10.1155/2021/9968463

    PMID: 34987599

    		 Sample: Serum
  46. ENVIRONMENTAL TOXICOLOGY (2019) IF: 2.649
    Nano‐selenium attenuates nickel‐induced testosterone synthesis disturbance through inhibition of MAPK pathways in Sprague‐Dawley rats

    DOI: 10.1002/tox.22768
    Sample: Serum
  47. Journal of Experimental Zoology Part A-Ecological and Integrative Physiology (2022) IF: 2.693
    Ameliorative effect of Vitis vinifera (Linn.) seed extract on lead acetate induced oxidative damage on testis and sperm quality in Wistar rats

    DOI: 10.1002/jez.2672
    Sample: Serum
  48. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION (2022) IF: 2.718
    Effects of ginger (Zingiber officinale) supplementation on testicular histology, semen characteristic, blood plasma parameters and reproductive performance in aged broiler breeder roosters

    DOI: 10.1111/jpn.13779
    Sample: Serum
  49. JOURNAL OF FOOD BIOCHEMISTRY (2021) IF: 2.72
    Chlorogenic acid co-administration abates tamoxifen-mediated reproductive toxicities in male rats: An experimental approach

    DOI: 10.1111/jfbc.13615

    PMID: 33491243

    		 Sample: Serum
  50. THERIOGENOLOGY (2021) IF: 2.74
    Reproductive characteristics, semen quality, seminal oxidative status, steroid hormones, sperm production efficiency of rabbits fed herbal supplements

    DOI: 10.1016/j.theriogenology.2021.03.020

    PMID: 33845263

    		 Sample: Serum
  51. ANDROLOGIA (2021) IF: 2.775
    Cysteamine mitigates torsion/detorsion-induced reperfusion injury via inhibition of apoptosis, oxidative stress and inflammatory responses in experimental rat model

    DOI: 10.1111/and.14243

    PMID: 34498746

    		 Sample: Serum
  52. ANDROLOGIA (2021) IF: 2.775
    Achillea millefolium alleviates testicular damage in paclitaxel-intoxicated rats via attenuation of testicular oxido-inflammatory stress and apoptotic responses

    DOI: 10.1111/and.14028

    PMID: 33650701

    		 Sample: Serum
  53. PLoS One (2017) IF: 2.806
    Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells

    DOI: 10.1371/journal.pone.0188029
    Sample: Cell Culture Supernatant
  54. Journal of Ginseng Research (2015) IF: 2.815
    In vitro and in vivo evaluation of tissue-cultured mountain ginseng on penile erection

    DOI: 10.1016/j.jgr.2015.10.003
    Sample: Serum
  55. Andrology (2020) IF: 2.86
    Orlistat attenuates obesity‐induced decline in steroidogenesis and spermatogenesis by up‐regulating steroidogenic genes

    DOI: 10.1111/andr.12824
    Sample: Tissue Homogenate
  56. JOURNAL OF APPLIED TOXICOLOGY (2018) IF: 2.909
    Maternal di‐(2‐ethylhexyl) phthalate exposure alters hepatic insulin signal transduction and glucoregulatory events in rat F1 male offspring

    DOI: 10.1002/jat.3764
    Sample: Serum
  57. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2019) IF: 2.914
    Stereoselective metabolism and potential adverse effects of chiral fungicide triadimenol on Eremias argus

    DOI: 10.1007/s11356-019-07205-4
  58. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2019) IF: 2.914
    Isolation, characterization, and therapeutic activity of bergenin from marlberry (Ardisia colorata Roxb.) leaf on diabetic testicular complications in Wistar albino rats

    DOI: 10.1007/s11356-019-04139-9

    PMID: 30648235

    		 Sample: Serum
  59. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2019) IF: 2.914
    Attenuation potentials of royal jelly against hydroxyurea-induced infertility through inhibiting oxidation and release of pro-inflammatory cytokines in male rats

    DOI: 10.1007/s11356-019-05521-3
    Sample: Serum
  60. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019) IF: 2.928
    Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR

    DOI: 10.3892/ijmm.2018.3977

    PMID: 30431108

    		 Sample: Serum
  61. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019) IF: 2.928
    Expression of FKBP52 in the ovaries of PCOS rats

    DOI: 10.3892/ijmm.2018.3998

    PMID: 30483787

    		 Sample: Serum
  62. Molecular Medicine Reports (2016) IF: 2.952
    Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction

    DOI: 10.3892/mmr.2016.5712
    Sample: Serum
  63. BIOLOGY OF REPRODUCTION (2019) IF: 2.96
    Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice

    DOI: 10.1093/biolre/ioz067
    Sample: Serum
  64. Journal of Ovarian Research (2020) IF: 2.989
    The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.

    DOI: 10.1186/s13048-020-00650-7
    Sample: Serum
  65. EXPERIMENTAL BIOLOGY AND MEDICINE (2019) IF: 3.005
    Candesartan in a rat model of testicular toxicity: New insight on its protective mechanism:

    DOI: 10.1177/1535370219842149
    Sample: Serum
  66. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020) IF: 3.056
    The gut-microbiota-testis axis mediated by the activation of the Nrf2 antioxidant pathway is related to prepuberal steroidogenesis disorders induced by di-(2-ethylhexyl) phthalate

    DOI: 10.1007/s11356-020-09854-2

    PMID: 32588312

    		 Sample: Serum,Tissue Homogenate
  67. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020) IF: 3.056
    Synergic effects of aerobic exercise and eugenol supplement on germ cell development and testicular tissue structure in chlorpyrifos-treated animal model

    DOI: 10.1007/s11356-020-08222-4
    Sample: Serum
  68. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020) IF: 3.056
    Kolaviron suppresses dysfunctional reproductive axis associated with multi-walled carbon nanotubes exposure in male rats

    DOI: 10.1007/s11356-020-10324-y

    PMID: 32812151

    		 Sample: Serum,Tissue Homogenate
  69. Reproductive Sciences (2021) IF: 3.06
    Reproductive Effects of Nicotinamide on Testicular Function and Structure in Old Male Rats: Oxidative, Apoptotic, Hormonal, and Morphological Analyses

    DOI: 10.1007/s43032-021-00647-7

    PMID: 34101148

    		 Sample: Testicular
  70. BRAIN RESEARCH BULLETIN (2019) IF: 3.103
    The role of gonadal hormones in the hypoglossal discharge activity of rats exposed to chronic intermittent hypoxia

    DOI: 10.1016/j.brainresbull.2019.04.017
    Sample: Serum
  71. BRAIN RESEARCH (2018) IF: 3.125
    Intracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats

    DOI: 10.1016/j.brainres.2018.08.020
    Sample: Plasma
  72. REPRODUCTIVE TOXICOLOGY (2021) IF: 3.143
    Weighted gene coexpression network analysis reveals ESR1, FLNA and Furin as hub genes for DEHP-induced prepubertal testicular injury

    DOI: 10.1016/j.reprotox.2021.10.011

    PMID: 34718101

    		 Sample: Serum
  73. REPRODUCTIVE TOXICOLOGY (2022) IF: 3.143
    Bisphenol A exposure advances puberty onset by changing Kiss1 expression firstly in arcuate nucleus at juvenile period in female rats

    DOI: 10.1016/j.reprotox.2022.04.005

    PMID: 35429613

    		 Sample: Serum
  74. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2021) IF: 3.168
    The Effect of Rooibos (Aspalathus linearis), Honeybush (Cyclopia intermedia) and Sutherlandia (Lessertia frutescens) on Testicular Insulin Signalling in Streptozotocin-Induced Diabetes in Wistar Rats

    DOI: 10.2147/DMSO.S285025
    Sample: Plasma
  75. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020) IF: 3.245
    Possible differences in the mechanism of malignant transformation of HaCaT cells by arsenite and its dimethyl metabolites, particularly dimethylthioarsenics

    DOI: 10.1016/j.jtemb.2020.126544
    Sample: Serum
  76. HUMAN & EXPERIMENTAL TOXICOLOGY (2023) IF: 3.247
    Thymol co-administration abrogates hexachlorobenzene-induced reproductive toxicities in male rats

    DOI: 10.1177/09603271221149201
    Sample: Serum
  77. GENERAL AND COMPARATIVE ENDOCRINOLOGY (2022) IF: 3.255
    Role and mechanism of the p-JAK2/p-STAT3 signaling pathway in follicular development in PCOS rats

    DOI: 10.1016/j.ygcen.2022.114138

    PMID: 36202220

    		 Sample: Serum
  78. International Journal of Endocrinology (2022) IF: 3.257
    Harmful Consequences of Proton Pump Inhibitors on Male Fertility: An Evidence from Subchronic Toxicity Study of Esomeprazole and Lansoprazole in Wistar Rats

    DOI: 10.1155/2022/4479261

    PMID: 35529080

    		 Sample: Serum
  79. Toxins (2018) IF: 3.273
    The Protective Role of Bacillus velezensis A2 on the Biochemical and Hepatic Toxicity of Zearalenone in Mice

    DOI: 10.3390/toxins10110449

    PMID: 30384460

    		 Sample: Serum
  80. NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2020) IF: 3.311
    Estrogen receptor (ESR1 and ESR2)-mediated activation of eNOS–NO–cGMP pathway facilitates high altitude acclimatization

    DOI: 10.1016/j.niox.2020.05.003
    Sample: Plasma
  81. BIOLOGY OF REPRODUCTION (2020) IF: 3.322
    Loss of Fbxw7 in Sertoli cells impairs testis development and causes infertility in mice

    DOI: 10.1093/biolre/ioz230
    Sample: Plasma
  82. POULTRY SCIENCE (2022) IF: 3.352
    Long-day photoperiods affect expression of OPN5 and the TSH-DIO2/DIO3 pathway in Magang goose ganders

    DOI: 10.1016/j.psj.2022.102024

    PMID: 35986948

    		 Sample: Serum
  83. POULTRY SCIENCE (2022) IF: 3.352
    Effects of stocking density on ovarian development and maturation during the rearing period in Shan-ma ducks

    DOI: 10.1016/j.psj.2022.101809

    PMID: 35358924

    		 Sample: Serum
  84. TOXICOLOGY LETTERS (2014) IF: 3.355
    Differential proteome and gene expression reveal response to carbon ion irradiation in pubertal mice testes

    DOI: 10.1016/j.toxlet.2014.01.001
    Sample: Serum
  85. CHEMICO-BIOLOGICAL INTERACTIONS (2019) IF: 3.407
    Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by suppressing elevated circulating testosterone

    DOI: 10.1016/j.cbi.2019.108742
    Sample: Plasma
  86. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2015) IF: 3.412
    Protective effects of metformin on reproductive function in obese male rats induced by high-fat diet

    DOI: 10.1007/s10815-015-0506-2
    Sample: Serum
  87. LIFE SCIENCES (2019) IF: 3.448
    Protective role of glutamine against cadmium-induced testicular dysfunction in Wistar rats: Involvement of G6PD activity

    DOI: 10.1016/j.lfs.2019.117250

    PMID: 31899225

    		 Sample: Serum
  88. TOXICOLOGY LETTERS (2019) IF: 3.499
    Cholestasis-associated reproductive toxicity in male and female rats: The fundamental role of mitochondrial impairment and oxidative stress

    DOI: 10.1016/j.toxlet.2019.09.009
    Sample: Serum
  89. European Review for Medical and Pharmacological Sciences (2022) IF: 3.507
    Spirulina therapeutic potentiality in polycystic ovarian syndrome management using DHEA-induced rat model.

    DOI: 10.26355/eurrev_202204_28604
    Sample: Serum
  90. Toxicology Research (2021) IF: 3.524
    The modulatory impacts of Glycyrrhiza glabra extract against methotrexate-induced testicular dysfunction and oxidative stress

    DOI: 10.1093/toxres/tfab049
    Sample: Serum
  91. TOXICOLOGY LETTERS (2020) IF: 3.569
    Downregulation of vdac2 inhibits spermatogenesis via JNK and P53 signalling in mice exposed to cadmium

    DOI: 10.1016/j.toxlet.2020.03.011

    PMID: 32199951

    		 Sample: Cell Culture Supernatant
  92. TOXICOLOGY AND APPLIED PHARMACOLOGY (2019) IF: 3.585
    High copper levels in follicular fluid affect follicle development in polycystic ovary syndrome patients: Population-based and in vitro studies

    DOI: 10.1016/j.taap.2019.01.008

    PMID: 30641075

    		 Sample: Serum,Cell Culture Medium
  93. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020) IF: 3.606
    Ameliorating effects of agomelatine on testicular and epididymal damage induced by methotrexate in rats

    DOI: 10.1002/jbt.22445

    PMID: 31975554

    		 Sample: Serum
  94. Endocrinology and Metabolism (2022) IF: 3.607
    Fancd2os Reduces Testosterone Production by Inhibiting Steroidogenic Enzymes and Promoting Cellular Apoptosis in Murine Testicular Leydig Cells

    DOI: 10.3803/EnM.2022.1431
    Sample: Serum,Tm3 Cell
  95. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021) IF: 3.652
    Abatement of the dysfunctional hypothalamic–pituitary–gonadal axis due to ciprofloxacin administration by selenium in male rats

    DOI: 10.1002/jbt.22741
    Sample: Serum
  96. GENE (2021) IF: 3.688
    Comparative transcriptome analysis reveals potential testosterone function-related regulatory genes/pathways of Leydig cells in immature and mature buffalo (Bubalus bubalis) testes

    DOI: 10.1016/j.gene.2021.145870

    PMID: 34363886

    		 Sample: Leydig Cells (Lcs)
  97. CHEMOSPHERE (2016) IF: 3.698
    Disruption of sex-hormone levels and steroidogenic-related gene expression on Mongolia Racerunner (Eremias argus) after exposure to triadimefon and its enantiomers

    DOI: 10.1016/j.chemosphere.2016.12.096
    Sample: Plasma
  98. BIOLOGICAL TRACE ELEMENT RESEARCH (2021) IF: 3.738
    Aluminum Chloride–Induced Reproductive Toxicity in Rats: the Protective Role of Zinc Oxide Nanoparticles

    DOI: 10.1007/s12011-021-03010-8
    Sample: Serum
  99. FOOD AND CHEMICAL TOXICOLOGY (2019) IF: 3.775
    Cadmium exposure during prenatal development causes testosterone disruption in multigeneration via SF-1 signaling in rats

    DOI: 10.1016/j.fct.2019.110897

    PMID: 31654709

    		 Sample: Serum
  100. REPRODUCTION (2021) IF: 3.906
    Parents ethanol use impairs ethanol-naive offspring development and reproduction

    DOI: 10.1530/REP-20-0316

    PMID: 33434152

    		 Sample: Plasma
  101. REPRODUCTION (2021) IF: 3.906
    Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway

    DOI: 10.1530/REP-20-0643

    PMID: 33989172

    		 Sample: Serum
  102. REPRODUCTION (2021) IF: 3.906
    CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells

    DOI: 10.1530/REP-20-0451

    PMID: 33258800

    		 Sample: Serum,Cell Culture Supernatant(Ovarian Granulosa C
  103. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2022) IF: 3.963
    Possible changes in trade-off strategy in female lizards (Eremias argus) during hibernation following exposure to chlorantraniliprole: Impact on the HPG axis and the energy mobilization

    DOI: 10.1016/j.pestbp.2022.105059

    PMID: 35715026

    		 Sample: Plasma
  104. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2018) IF: 3.974
    Sulphur dioxide and arsenic affect male reproduction via interfering with spermatogenesis in mice

    DOI: 10.1016/j.ecoenv.2018.08.109

    PMID: 30195209

    		 Sample: Serum
  105. Scientific Reports (2020) IF: 3.998
    Reproductive effects of subchronic exposure to acetamiprid in male rats

    DOI: 10.1038/s41598-020-65887-0

    PMID: 32488017

    		 Sample: Plasma,Tissue Homogenate
  106. Scientific Reports (2019) IF: 4.011
    Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes

    DOI: 10.1038/s41598-019-42377-6
    Sample: Plasma
  107. SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2022) IF: 4.052
    Evaluation of testicular torsion management in Ogbomoso, South-Western Nigeria and surgical detorsion-augmented treatment with phytochemical fractions of Corchorus olitorius leaf in experimental rats

    DOI: 10.1016/j.sjbs.2022.103495
    Sample: Testicular Tissue
  108. BIOCHIMIE (2021) IF: 4.079
    Rescue effect of sodium acetate in diabetes mellitus-associated testicular dysfunction is accompanied by PCSK9 modulation

    DOI: 10.1016/j.biochi.2021.02.004

    PMID: 33581194

    		 Sample: Serum
  109. BIOLOGICAL TRACE ELEMENT RESEARCH (2023) IF: 4.081
    Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats

    DOI: 10.1007/s12011-023-03579-2
    Sample: Serum
  110. Genes (2021) IF: 4.096
    DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis

    DOI: 10.3390/genes12111800

    PMID: 34828406

    		 Sample: Plasma
  111. TOXICOLOGY (2020) IF: 4.099
    Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats

    DOI: 10.1016/j.tox.2020.152556

    PMID: 32758512

    		 Sample: Serum,Tissue Homogenate
  112. Journal of Translational Medicine (2020) IF: 4.124
    Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis

    DOI: 10.1186/s12967-020-02249-4
    Sample: Serum
  113. BIOLOGY OF REPRODUCTION (2022) IF: 4.161
    Maternal exposure of rats to sodium saccharin during gestation and lactation on male offspring

    DOI: 10.1093/biolre/ioac190

    PMID: 36219170

    		 Sample: Plasma
  114. Food & Function (2020) IF: 4.171
    Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota

    DOI: 10.1039/C9FO02554E

    PMID: 32441726

    		 Sample: Serum
  115. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019) IF: 4.183
    Sulforaphane Protect Against Cadmium-Induced Oxidative Damage in mouse Leydigs Cells by Activating Nrf2/ARE Signaling Pathway

    DOI: 10.3390/ijms20030630

    PMID: 30717178

    		 Sample: Tissue Homogenate
  116. TOXICOLOGY (2021) IF: 4.221
    Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice

    DOI: 10.1016/j.tox.2021.152860

    PMID: 34280466

    		 Sample: Serum
  117. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021) IF: 4.223
    Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure

    DOI: 10.1007/s11356-021-16701-5

    PMID: 34595713

    		 Sample: Serum
  118. Frontiers in Pharmacology (2020) IF: 4.225
    Wuzi Yanzong Pill—Based on Network Pharmacology and In Vivo Evidence—Protects Against Spermatogenesis Disorder via the Regulation of the Apoptosis Pathway

    DOI: 10.3389/fphar.2020.592827
    Sample: Serum
  119. Scientific Reports (2017) IF: 4.259
    Diet-induced obesity impairs spermatogenesis: a potential role for autophagy

    DOI: 10.1038/srep43475
    Sample: Serum
  120. Toxin Reviews (2021) IF: 4.266
    Benzo-a-pyrene-induced reproductive toxicity was abated in rats co-treated with taurine

    DOI: 10.1080/15569543.2021.1949617
    Sample: Serum
  121. BIOLOGY OF REPRODUCTION (2022) IF: 4.285
    Loss of raptor induces Sertoli cells into an undifferentiated state in mice

    DOI: 10.1093/biolre/ioac104

    PMID: 35594452

    		 Sample: Gonads
  122. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021) IF: 4.31
    Bee bread mitigates downregulation of steroidogenic genes, decreased spermatogenesis, and epididymal oxidative stress in male rats fed with high-fat diet

    DOI: 10.1152/ajpendo.00093.2021

    PMID: 34229480

    		 Sample: Serum,Testis
  123. ENVIRONMENTAL POLLUTION (2018) IF: 4.358
    Hepatotoxicity and reproductive disruption in male lizards (Eremias argus) exposed to glufosinate-ammonium contaminated soil

    DOI: 10.1016/j.envpol.2018.12.004

    PMID: 30543945

    		 Sample: Plasma
  124. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    In vivo and in vitro protective effects of the Wuzi Yanzong pill against experimental spermatogenesis disorder by promoting germ cell proliferation and suppressing apoptosis

    DOI: 10.1016/j.jep.2021.114443

    PMID: 34302943

    		 Sample: Serum
  125. TOXICOLOGY LETTERS (2017) IF: 4.374
    Dual effects of sulfasalazine on rat sperm characteristics, spermatogenesis, and steroidogenesis in two experimental models

    DOI: 10.1016/j.toxlet.2017.11.034
    Sample: Serum
  126. TOXICOLOGY LETTERS (2021) IF: 4.374
    Copper exposure disrupts ovarian steroidogenesis in human ovarian granulosa cells via the FSHR/CYP19A1 pathway and alters methylation patterns on the SF-1 gene promoter

    DOI: 10.1016/j.toxlet.2021.12.002

    PMID: 34871762

    		 Sample: Ovarian Granulosa Cell
  127. Scientific Reports (2022) IF: 4.38
    Testicular ultrastructure and hormonal changes following administration of tenofovir disoproxil fumarate-loaded silver nanoparticle in type-2 diabetic rats

    DOI: 10.1038/s41598-022-13321-y

    PMID: 35688844

    		 Sample: Serum
  128. MOLECULES (2021) IF: 4.412
    The Physicochemical Characteristics of Gelam Honey and Its Outcome on the Female Reproductive Tissue of Sprague–Dawley Rats: A Preliminary Study

    DOI: 10.3390/molecules26113346
    Sample: Serum
  129. JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2018) IF: 4.414
    Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: roles of adenosine deaminase and xanthine oxidase activities

    DOI: 10.1016/j.jnutbio.2018.08.018
    Sample: Plasma
  130. International Journal of Nanomedicine (2019) IF: 4.471
    CeO2NPs relieve radiofrequency radiation, improve testosterone synthesis, and clock gene expression in Leydig cells by enhancing antioxidation

    DOI: 10.2147/IJN.S206561
    Sample: Leydig Cells
  131. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2019) IF: 4.527
    Ecological risk assessment of alpha-cypermethrin-treated food ingestion and reproductive toxicity in reptiles

    DOI: 10.1016/j.ecoenv.2019.01.012

    PMID: 30658301

    		 Sample: Serum
  132. Frontiers in Physiology (2021) IF: 4.566
    Human Physiological Responses to a Single Deep Helium-Oxygen Diving

    DOI: 10.3389/fphys.2021.735986
    Sample: Saliva
  133. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020) IF: 4.872
    LncRNAs activate longevity regulation pathway due to aging of Leydig cells caused by DEHP exposure: A transcriptome-based study

    DOI: 10.1016/j.ecoenv.2020.111798

    PMID: 33360214

    		 Sample: Cell Culture Supernatant
  134. NUTRITION (2022) IF: 4.893
    Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3

    DOI: 10.1016/j.nut.2022.111914
    Sample: Plasma
  135. Journal of Clinical Medicine (2022) IF: 4.964
    Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome

    DOI: 10.3390/jcm11195584

    PMID: 36233452

    		 Sample: Serum
  136. Scientific Reports (2022) IF: 4.996
    Effects of Cordyceps militaris fermentation products on reproductive development in juvenile male mice

    DOI: 10.1038/s41598-022-18066-2

    PMID: 35962055

    		 Sample: Serum
  137. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2022) IF: 5.011
    Acetate: A therapeutic candidate against renal disorder in a rat model of polycystic ovarian syndrome

    DOI: 10.1016/j.jsbmb.2022.106179

    PMID: 36150640

    		 Sample: Plasma
  138. LIFE SCIENCES (2022) IF: 5.037
    Studies on testicular ultrastructural and hormonal changes in type-2 diabetic rats treated with highly active antiretroviral therapy conjugated silver nanoparticles

    DOI: 10.1016/j.lfs.2022.120498

    PMID: 35341824

    		 Sample: Serum
  139. LIFE SCIENCES (2021) IF: 5.037
    Evaluation of maternal high-fat diet and Quercetin-3-O-rutinoside treatment on the reproductive profile of diet naïve male offspring

    DOI: 10.1016/j.lfs.2021.119179

    PMID: 33577849

    		 Sample: Tissue Homogenate
  140. Reproductive Biology and Endocrinology (2021) IF: 5.211
    Irisin deletion induces a decrease in growth and fertility in mice

    DOI: 10.1186/s12958-021-00702-7

    PMID: 33581723

    		 Sample: Serum
  141. Reproductive Biology and Endocrinology (2021) IF: 5.211
    Icariin improves testicular dysfunction via enhancing proliferation and inhibiting mitochondria-dependent apoptosis pathway in high-fat diet and streptozotocin-induced diabetic rats

    DOI: 10.1186/s12958-021-00851-9

    PMID: 34753504

    		 Sample: Serum
  142. Reproductive Biology and Endocrinology (2022) IF: 5.211
    Oral Medicine Research (2019)

    DOI: 10.1186/s12958-022-00949-8

    PMID: 35597951

    		 Sample: Serum
  143. Scientific Reports (2016) IF: 5.228
    ELISA Kits for Cell Biology Research

    DOI: 10.1038/srep21776
    Sample: Serum
  144. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021) IF: 5.31
    Oxidized high-density lipoprotein enhances endocrine disorders and ovarian damage in rats

    DOI: 10.1111/jcmm.16197

    PMID: 34346538

    		 Sample: Serum
  145. Food & Function (2022) IF: 5.396
    Lactiplantibacillus plantarum CCFM1019 attenuate polycystic ovary syndrome through butyrate dependent gut–brain mechanism

    DOI: 10.1039/D1FO01744F

    PMID: 35044398

    		 Sample: Serum
  146. FOOD AND CHEMICAL TOXICOLOGY (2023) IF: 5.572
    Polystyrene nanoplastics inhibit StAR expression by activating HIF-1α via ERK1/2 MAPK and AKT pathways in TM3 Leydig cells and testicular tissues of mice

    DOI: 10.1016/j.fct.2023.113634
    Sample: Testis,Serum
  147. FOOD AND CHEMICAL TOXICOLOGY (2022) IF: 5.572
    Exposure to acrylamide inhibits testosterone production in mice testes and Leydig cells by activating ERK1/2 phosphorylation

    DOI: 10.1016/j.fct.2022.113576
    Sample: Serum,Tm3 Leydig Cells
  148. SCIENCE OF THE TOTAL ENVIRONMENT (2019) IF: 5.589
    Accumulation and toxicity of thiamethoxam and its metabolite clothianidin to the gonads of Eremias argus

    DOI: 10.1016/j.scitotenv.2019.02.419

    PMID: 30833257

    		 Sample: Plasma
  149. Artificial Cells Nanomedicine and Biotechnology (2021) IF: 5.678
    Effects of vancomycin linoleic acid nanoparticles on male reproductive indices of Sprague–Dawley rats

    DOI: 10.1080/21691401.2021.1968883
    Sample: Serum
  150. Aging-US (2021) IF: 5.682
    Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome via inactivation of TGF-β1/Smads signaling pathway in vivo

    DOI: 10.18632/aging.202564

    PMID: 33638949

    		 Sample: Serum
  151. ENVIRONMENTAL POLLUTION (2019) IF: 5.714
    Gonadal disruption after single dose exposure of prothioconazole and prothioconazole-desthio in male lizards (Eremias argus)

    DOI: 10.1016/j.envpol.2019.113297
    Sample: Serum
  152. ENVIRONMENTAL POLLUTION (2019) IF: 5.714
    Enrichment of imidacloprid and its metabolites in lizards and its toxic effects on gonads

    DOI: 10.1016/j.envpol.2019.113748

    PMID: 31874432

    		 Sample: Plasma
  153. CHEMOSPHERE (2020) IF: 5.778
    Effects of fluoride on PIWI-interacting RNA expression profiling in testis of mice

    DOI: 10.1016/j.chemosphere.2020.128727

    PMID: 33213873

    		 Sample: Serum
  154. Frontiers in Pharmacology (2021) IF: 5.811
    Icariin Ameliorates Diabetic Renal Tubulointerstitial Fibrosis by Restoring Autophagy via Regulation of the miR-192-5p/GLP-1R Pathway

    DOI: 10.3389/fphar.2021.720387
    Sample: Serum
  155. Cell Death & Disease (2017) IF: 5.965
    ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats

    DOI: 10.1038/cddis.2017.494
    Sample: Serum
  156. Frontiers in Endocrinology (2022) IF: 6.055
    Role of EGFR expressed on the granulosa cells in the pathogenesis of polycystic ovarian syndrome.

    DOI: 10.3389/fendo.2022.971564
    Sample: Serum
  157. International Journal of Nanomedicine (2022) IF: 6.4
    Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway

    DOI: 10.2147/IJN.S348673

    PMID: 35401001

    		 Sample: Serum
  158. International Journal of Nanomedicine (2021) IF: 6.4
    Development and Evaluation of Curcumin Encapsulated Self-assembled Nanoparticles as Potential Remedial Treatment for PCOS in a Female Rat Model

    DOI: 10.2147/IJN.S302161

    PMID: 34531655

    		 Sample: Serum
  159. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway

    DOI: 10.1016/j.biopha.2022.113061

    PMID: 35658231

    		 Sample: Serum
  160. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats

    DOI: 10.1016/j.biopha.2022.112870

    PMID: 35367769

    		 Sample: Serum
  161. Oxidative Medicine and Cellular Longevity (2021) IF: 6.543
    Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats

    DOI: 10.1155/2021/7382900
    Sample: Serum
  162. SCIENCE OF THE TOTAL ENVIRONMENT (2020) IF: 6.551
    Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice

    DOI: 10.1016/j.scitotenv.2020.141049
    Sample: Serum
  163. Cells (2022) IF: 6.6
    Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway

    DOI: 10.3390/cells11101690

    PMID: 35626727

    		 Sample: Serum,Testicular Tissue
  164. ENVIRONMENTAL POLLUTION (2020) IF: 6.793
    Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury

    DOI: 10.1016/j.envpol.2020.113911

    PMID: 31923814

    		 Sample: Tissue Homogenate
  165. ENVIRONMENTAL POLLUTION (2020) IF: 6.793
    Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury☆

    DOI: 10.1016/j.envpol.2020.115627
    Sample: Cell Sample
  166. ENVIRONMENTAL POLLUTION (2020) IF: 6.793
    Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury☆

    DOI: 10.1016/j.envpol.2020.115627
    Sample: Cell Culture Supernatant
  167. ENVIRONMENTAL POLLUTION (2020) IF: 6.793
    Environmental relevant concentration of λ-cyhalothrin and 3-phenoxybenzoic acid caused endocrine-disrupting effects on male lizards (Eremias argus)

    DOI: 10.1016/j.envpol.2020.115077
    Sample: Plasma
  168. CHEMOSPHERE (2020) IF: 7.086
    Interleukin 17A deficiency alleviates fluoride-induced testicular injury by inhibiting the immune response and apoptosis

    DOI: 10.1016/j.chemosphere.2020.128178
    Sample: Serum
  169. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2023) IF: 7.129
    p38 mediates T-2 toxin-induced Leydig cell testosterone synthesis disorder

    DOI: 10.1016/j.ecoenv.2023.114695
    Sample: Testis,Tm3 Cell
  170. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022) IF: 7.129
    Alleviating effects of selenium on fluoride-induced testosterone synthesis disorder and reproduction toxicity in rats

    DOI: 10.1016/j.ecoenv.2022.114249

    PMID: 36323150

    		 Sample: Testis
  171. Oxidative Medicine and Cellular Longevity (2022) IF: 7.31
    Curcumin Inhibits Hyperandrogen-Induced IRE1α-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats

    DOI: 10.1155/2022/2113293
    Sample: Serum
  172. Antioxidants (2022) IF: 7.675
    Kelulut Honey Ameliorates Oestrus Cycle, Hormonal Profiles, and Oxidative Stress in Letrozole-Induced Polycystic Ovary Syndrome Rats

    DOI: 10.3390/antiox11101879

    PMID: 36290602

    		 Sample: Serum
  173. SCIENCE OF THE TOTAL ENVIRONMENT (2021) IF: 7.963
    Effects of acute exposure to microcystins on hypothalamic-pituitary-adrenal (HPA), -gonad (HPG) and -thyroid (HPT) axes of female rats

    DOI: 10.1016/j.scitotenv.2021.145196

    PMID: 34030373

    		 Sample: Serum
  174. JOURNAL OF HAZARDOUS MATERIALS (2020) IF: 9.038
    Multiple transcriptomic profiling: p53 signaling pathway is involved in DEHP-induced prepubertal testicular injury via promoting cell apoptosis and inhibiting cell proliferation of Leydig cells

    DOI: 10.1016/j.jhazmat.2020.124316

    PMID: 33162236

    		 Sample: Serum
  175. CARBOHYDRATE POLYMERS (2022) IF: 9.381
    Butylated starch alleviates polycystic ovary syndrome by stimulating the secretion of peptide tyrosine-tyrosine and regulating faecal microbiota

    DOI: 10.1016/j.carbpol.2022.119304

    PMID: 35422283

    		 Sample: Serum
  176. Particle and Fibre Toxicology (2022) IF: 9.4
    Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway

    DOI: 10.1186/s12989-022-00453-2

    PMID: 35177090

    		 Sample: Serum
  177. JOURNAL OF HAZARDOUS MATERIALS (2020) IF: 10.588
    Polystyrene microplastics induced male reproductive toxicity in mice

    DOI: 10.1016/j.jhazmat.2020.123430

    PMID: 32659591

    		 Sample: Serum
  178. JOURNAL OF HAZARDOUS MATERIALS (2021) IF: 10.588
    Di (2-ethyl-hexyl) phthalate disrupts placental growth in a dual blocking mode

    DOI: 10.1016/j.jhazmat.2021.126815
    Sample: Serum
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Reviews/Q&A

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  • Reviews
  • Q&A
Q

D******************OSubmitted [ Jun 25 2024 ]

Asked: Hello, is this kit suitable for canine serum samples? Best regards, David.

Reply

A

adminSubmitted [ Jun 25 2024 ]

Answered: Thanks for your message. We will contact you through the email very soon.

A

adminSubmitted [ Jun 25 2024 ]

Answered: We have validated E-EL-0155 with normal canine serum, samples were diluted at 2-5 fold and the reference value was about 2-12ng/mL.

Q

S*********nSubmitted [ Aug 15 2023 ]

Asked: Is it suitable for a mouse?

Reply

A

adminSubmitted [ Aug 15 2023 ]

Answered: E-OSEL-M0003 QuicKey Pro Mouse T(Testosterone)ELISA Kit the kit is suitable for mouse samples.

Q

G*****dSubmitted [ May 03 2022 ]

Asked: Hello, In the ELISA kit E-EL-0155, did we measure free or total testosterone ? Best regards, Geraldine

Reply

A

adminSubmitted [ May 03 2022 ]

Answered: Hi Geraldine, this kit measures Total Testosterone. Feel free to contact us if you have any other questions.

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