Alternate Names	Killer cell lectin-like receptor subfamily B member 1C,Klrb1c,CD161 antigen-like family member C,Ly-55c,CD161/NK1.1,NKR-P1.9,NKR-P1C,NKR-P1 40,CD161c
Swissprot	P27814,P27812,Q99JB4
References	1. Lanier LL. 1997. Immunity 6:371. 2. Yokoyama WM, et al. 1993. Ann. Rev. Immunol. 11:613. 3. Koo GC, et al. 1986. J. Immunol. 137:3742. 4. Giorda R, et al. 1991. J. Immunol. 147:1701.

Product Details

Form	Liquid
Clone No.	PK136
Host	Mouse
Isotype	Mouse IgG2a, κ
Isotype Control	APC Mouse IgG2a, κ Isotype Control[C1.18.4] [Product E-AB-F09803E]
Reactivity	Mouse
Application	FCM
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use	Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10⁶ cells in 100 μL volume].
Shipping	Biological ice pack at 4℃
Stability & Storage	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Conjugation	APC
	APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).

How to select the appropriate detection channel through the spectrogram?

Background

NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

Protocols & Troubleshootings

Related Protocols	Staining Cell Surface Targets for Flow Cytometry
Troubleshooting	Troubleshooting for Flow Cytometry

Alternative Formats

Product Name	Sizes	Price
AF/LE Purified Anti-Mouse CD161/NK1.1 Antibody[PK136]	50μg, 500μg, 1mg	Check More
Purified Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
Biotin Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
FITC Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
PE Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
APC Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
PE/Cyanine5 Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
PE/Cyanine7 Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
PE/Cyanine5.5 Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
PerCP/Cyanine5.5 Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
Elab Fluor^® 488 Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
Elab Fluor^® 647 Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
Elab Fluor^® Violet 450 Anti-Mouse CD161/NK1.1 Antibody[PK136]	50Tests, 100Tests, 100Tests×2	Check More
FITC Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
PE Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
PE/Cyanine5 Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
PE/Cyanine7 Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
PE/Cyanine5.5 Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
PerCP/Cyanine5.5 Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
Elab Fluor^® 488 Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
Elab Fluor^® 647 Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More
Elab Fluor^® Violet 450 Anti-Mouse CD161/NK1.1 Antibody[PK136]	25μg, 100μg	Check More

Citations

Cancers (2022) IF: 6.575

IL-2K35C-moFA, a Long-Acting Engineered Cytokine with Decreased Interleukin 2 Receptor α Binding, Improved the Cellular Selectivity Profile and Antitumor Efficacy in a Mouse Tumor Model

DOI: 10.3390/cancers14194742
	Sample: Spleen Single-Cell

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